194163-01-4

Basic information

• Product Name: 2-Heptenoic acid, 3-phenyl-7-[[(phenylmethoxy)carbonyl]amino]-, 1,1-dimethylethyl ester
• CAS NO: 194163-01-4
• Molecular Formula: C25H31NO4
• Molecular Weight: 409.525
• Mol File: 194163-01-4.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 2-Heptenoic acid, 3-phenyl-7-[[(phenylmethoxy)carbonyl]amino]-, 1,1-dimethylethyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Heptenoic acid, 3-phenyl-7-[[(phenylmethoxy)carbonyl]amino]-, 1,1-dimethylethyl ester(194163-01-4)
• EPA Substance Registry System: 2-Heptenoic acid, 3-phenyl-7-[[(phenylmethoxy)carbonyl]amino]-, 1,1-dimethylethyl ester(194163-01-4)

Safety Data

• Hazardous Substances Data: 194163-01-4(Hazardous Substances Data)

Upstream product

• 660-88-8 5-aminopentanoic acid 
• 169463-91-6 [4-(Methoxy-methyl-carbamoyl)-butyl]-carbamic acid benzyl ester 
• 501-53-1 benzyl chloroformate 
• 23135-50-4 5-(N-benzyloxycarbonylamino)pentanoic acid 
• 27784-76-5 tert-butyl diethylphosphonoacetate 
• 119174-36-6 benzyl [N-(5-phenyl-5-oxopentyl)amino]methanoate 

Downstream Products

• 1027371-97-6 3-Phenyl-7-[(5-thiocarbamoyl-1H-indole-2-carbonyl)-amino]-heptanoic acid tert-butyl ester 
• 1027262-37-8 7-[(5-Carbamimidoyl-1H-indole-2-carbonyl)-amino]-3-phenyl-heptanoic acid tert-butyl ester 
• 194162-86-2 7-[(5-Cyano-1H-indole-2-carbonyl)-amino]-3-phenyl-heptanoic acid tert-butyl ester 
• 1026837-34-2 7-Amino-3-phenyl-heptanoic acid tert-butyl ester 

Relevant articles and documents

Use of conformationally restricted benzamidines as arginine surrogates in the design of platelet GPIIb-IIIa receptor antagonists

The use of 5,6-bicyclic amidines as arginine surrogates in the design of a novel class of potent platelet glycoprotein IIb-IIIa receptor (GPIIb-IIIa) antagonists is described. The additional conformational restriction offered by the bicyclic nucleus results in 20-400-fold increases in potency compared to the freely flexible, acyclic benzamidine counterpart. The design, synthesis, structure-activity relationships (SAR), and in vitro activity of this novel class of GPIIb-IIIa antagonists are presented.