19420-53-2

Basic information

• Product Name: Piperidine, 1-(tetrahydro-4-phenyl-2H-thiopyran-4-yl)-
• CAS NO: 19420-53-2
• Molecular Formula: C16H23NS
• Molecular Weight: 261.431
• Mol File: 19420-53-2.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: Piperidine, 1-(tetrahydro-4-phenyl-2H-thiopyran-4-yl)-(CAS DataBase Reference)
• NIST Chemistry Reference: Piperidine, 1-(tetrahydro-4-phenyl-2H-thiopyran-4-yl)-(19420-53-2)
• EPA Substance Registry System: Piperidine, 1-(tetrahydro-4-phenyl-2H-thiopyran-4-yl)-(19420-53-2)

Safety Data

• Hazardous Substances Data: 19420-53-2(Hazardous Substances Data)

Upstream product

• 1072-72-6 Tetrahydrothiopyran-4-one 
• 110-89-4 piperidine 
• 59397-53-4 4-piperidin-1-yl-tetrahydrothiopyran-4-carbonitrile 
• 100-58-3 phenylmagnesium bromide 

Relevant articles and documents

Effect of lowered lipophilicity on the affinity of PCP analogues for the PCP receptor and the dopamine transporter

Oxygen and sulphur atoms were introduced in the cyclohexyl and piperidinyl moieties of the basic structures 1-(1-phenyl-cyclohexyl)piperidine (PCP), 1- [1-(2-thienyl)cyclohexyl]piperidine (TCP), and 1-[1-(2- benzo[b]thiophenyl)cyclohexyl]piperidine (BTCP) to lower their global lipophilicity. The compounds obtained were tested comparatively for their affinity for the PCP receptor labelled with [3H]TCP and for the dopamine (DA) transporter labelled with [3H]BTCP. Lowering the global lipophilicity in PCP and TCP series is detrimental to the affinity and selectivity for the PCP receptor. In the BTCP series lowering of the global lipophilicity is less deleterious and may, on the contrary, be a useful way of increasing selectivity for the DA transporter in some instances.