194206-09-2

Basic information

• Product Name: methyl N^α-[(1-benzyloxycarbonylindolin-5-yl)carbonyl]-N^δ-[2-(ethoxycarbonyl)cyclopropylcarbonyl]-L-ornithinate
• Synonyms: methyl N^α-[(1-benzyloxycarbonylindolin-5-yl)carbonyl]-N^δ-[2-(ethoxycarbonyl)cyclopropylcarbonyl]-L-ornithinate
• CAS NO: 194206-09-2
• Molecular Weight: 565.623
• Mol File: 194206-09-2.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: methyl N^α-[(1-benzyloxycarbonylindolin-5-yl)carbonyl]-N^δ-[2-(ethoxycarbonyl)cyclopropylcarbonyl]-L-ornithinate(CAS DataBase Reference)
• NIST Chemistry Reference: methyl N^α-[(1-benzyloxycarbonylindolin-5-yl)carbonyl]-N^δ-[2-(ethoxycarbonyl)cyclopropylcarbonyl]-L-ornithinate(194206-09-2)
• EPA Substance Registry System: methyl N^α-[(1-benzyloxycarbonylindolin-5-yl)carbonyl]-N^δ-[2-(ethoxycarbonyl)cyclopropylcarbonyl]-L-ornithinate(194206-09-2)

Safety Data

• Hazardous Substances Data: 194206-09-2(Hazardous Substances Data)

Upstream product

• 1055036-70-8 2-((S)-4-Benzyloxycarbonylamino-4-carboxy-butylcarbamoyl)-cyclopropanecarboxylic acid ethyl ester 
• 194206-02-5 methyl N^α-benzyloxycarbonyl-N^δ-[2-(ethoxycarbonyl)cyclopropylcarbonyl]-L-orthinate 
• 178687-20-2 2-chlorocarbonyl-cyclopropanecarboxylic acid ethyl ester 
• 142165-63-7 1-carbobenzoxy-5-carboxyindoline 
• 167113-73-7 D,L-Trans-2-Ethoxycarbonylcyclopropane-1-carboxylic acid 
• 2640-58-6 Nα-benzyloxycarbonyl-L-ornithine 
• 156578-52-8 5-Chlorocarbonyl-2,3-dihydro-indole-1-carboxylic acid benzyl ester 
• 194206-06-9 methyl N^δ-[2-(ethoxycarbonyl)cyclopropylcarbonyl]-L-orthinate 

Relevant articles and documents

Antirheumatic agents. III. Novel methotrexate derivatives bearing an indoline ring and a modified ornithine or glutamie acid

The synthesis, biological profile and structure-activity relationship of various methotrexate (MTX) derivatives bearing an indoline ring are described. In particular, Nδ-(3-carboxyphenyl)-Nα-[1-[(2,4-diaminopteridin- 6-yl)methyl]indoline-5-ylcarbonyl]-L-glutamine (3d), compared to MTX; exhibited an enhanced anti-proliferative effect on human peripheral blood mononuclear cells obtained from healthy volunteers.