194424-10-7

Basic information

• Product Name: Glutamic acid, N-[4-[[3-(ethoxycarbonyl)-6-(trifluoromethyl)-2-quinoxalinyl]amino]benzo yl]-, diethyl ester
• CAS NO: 194424-10-7
• Molecular Formula: C28H29F3N4O7
• Molecular Weight: 590.556
• Mol File: 194424-10-7.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: Glutamic acid, N-[4-[[3-(ethoxycarbonyl)-6-(trifluoromethyl)-2-quinoxalinyl]amino]benzo yl]-, diethyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: Glutamic acid, N-[4-[[3-(ethoxycarbonyl)-6-(trifluoromethyl)-2-quinoxalinyl]amino]benzo yl]-, diethyl ester(194424-10-7)
• EPA Substance Registry System: Glutamic acid, N-[4-[[3-(ethoxycarbonyl)-6-(trifluoromethyl)-2-quinoxalinyl]amino]benzo yl]-, diethyl ester(194424-10-7)

Safety Data

• Hazardous Substances Data: 194424-10-7(Hazardous Substances Data)

Upstream product

• 368-71-8 4-(trifluoromethyl)-1,2-phenylenediamine 
• 143948-79-2 ethyl 3-oxo-7-(trifluoromethyl)-3,4-dihydroquinoxaline-2-carboxylate 
• 13726-52-8 diethyl N-(p-aminobenzoyl)-L-glutamate 
• 194423-79-5 ethyl 3-chloro-7-(trifluoromethyl)quinoxaline-2-carboxylate 

Relevant articles and documents

Quinoxaline chemistry. Part 7. 2-[aminobenzoates]- and 2- [aminobenzoylglutamate]-quinoxalines as classical antifolate agents. Synthesis and evaluation of in vitro anticancer, anti-HIV and antifungal activity

Thirty-three quinoxalines bearing an aminobenxoyl or aminobenzoylglutammate group on position 2 and various substituents on position 3,6,7 of the heterocycle were prepared in order to evaluate in vitro anticancer activity. Preliminary screening performed at NCI showed that most derivatives exhibited a moderate to strong growth inhibition activity on various tumor panel cell lines between 10-5 and 10-4 molar concentrations. Interesting selectivities were also recorded between 10-8 and 10-6. Among the series examined one compound (29) which was the most active also exhibited both in vitro anti-HIV protection and antifungal activity while in other two (31.37) the antifungal activity was prevailing.