194490-33-0

Basic information

• Product Name: Methyl 3-cyano-1H-indole-5-carboxylate
• Synonyms: Methyl 3-cyano-1H-indole-5-carboxylate;3-Cyano-1H-indole-5-carboxylic acid methyl ester;1H-INDOLE-5-CARBOXYLIC ACID, 3-CYANO-, METHYL ESTER
• CAS NO: 194490-33-0
• Molecular Formula: C11H8N2O2
• Molecular Weight: 200.19342
• Mol File: 194490-33-0.mol
• Article Data: 3

Chemical Properties

• Appearance: /
• Storage Temp.: 2-8°C
• CAS DataBase Reference: Methyl 3-cyano-1H-indole-5-carboxylate(CAS DataBase Reference)
• NIST Chemistry Reference: Methyl 3-cyano-1H-indole-5-carboxylate(194490-33-0)
• EPA Substance Registry System: Methyl 3-cyano-1H-indole-5-carboxylate(194490-33-0)

Safety Data

• Hazardous Substances Data: 194490-33-0(Hazardous Substances Data)

Usage

General Description

Methyl 3-cyano-1H-indole-5-carboxylate is a chemical compound with the molecular formula C13H10N2O2. It is a derivative of indole, a heterocyclic organic compound that is commonly found in various natural products and pharmaceuticals. Methyl 3-cyano-1H-indole-5-carboxylate is a yellow-to-orange solid that is often used as a building block in organic synthesis for the preparation of various pharmaceuticals, agrochemicals, and other fine chemicals. It has potential applications in the development of new drugs and materials, and its versatile chemical properties make it an important intermediate in the field of organic chemistry. However, as with all chemicals, proper handling and safety precautions should be taken when working with this compound.

Upstream product

• 135205-66-2 N?cyanosuccinimide 
• 1011-65-0 5-methoxycarbonylindole 
• 197506-83-5 methyl 3‐formyl‐1H‐indole‐5‐carboxylate 
• 148563-41-1 3-formylindole-5-carboxylic acid 

Relevant articles and documents

GaCl3-Catalyzed C-H Cyanation of Indoles with N-Cyanosuccinimide

An efficient GaCl3-catalyzed direct cyanation of indoles and pyrroles using bench-stable electrophilic cyanating agent N-cyanosuccinimide was achieved and afforded 3-cyanoindoles and 2-cyanopyrroles in good yields and excellent regioselectivities. Notably, this protocol exhibited high reactivity for unprotected indoles and was applicable to a broad range of indole and pyrrole substrates.

Thiazolylbenzofuran derivatives and pharmaceutical compositions containing them

This invention relates to novel thiazolylbenzofuran derivatives of formula (I) wherein R1 is lower alkyl, L is single bond or lower alkylene optionally substituted with aryl, oxo or hydroxy, and Q is a heterocyclic group optionally substituted with one or more suitable substituent(s); or lower alkoxy substituted with aryl which is substituted with one or more suitable substituent(s) and at least one of which is lower alkoxy optionally substituted with cyano, protected carboxy, carboxy, lower alkylene, a heterocyclic group optionally substituted with oxo, or amidino optionally substituted with hydroxy or lower alkoxy, or its salt, which possess activities as leukotriene and SRS-A antagonists or inhibitors.