19457-37-5

Basic information

• Product Name: batrachotoxinin A
• Synonyms: batrachotoxinin A;(20S)-22-Methyl-3α,9α-epoxy-14β,18-(epoxyethanimino)-5β-pregna-7,16-diene-3β,11α,20-triol
• CAS NO: 19457-37-5
• Molecular Formula: C₂₄H₃₅NO₅
• Molecular Weight: 417.55
• Mol File: 19457-37-5.mol
• Article Data: 2

Chemical Properties

• Boiling Point: 623.7°Cat760mmHg
• Flash Point: 331°C
• Appearance: /
• Density: 1.34g/cm³
• Vapor Pressure: 3.59E-18mmHg at 25°C
• Refractive Index: 1.643
• CAS DataBase Reference: batrachotoxinin A(CAS DataBase Reference)
• NIST Chemistry Reference: batrachotoxinin A(19457-37-5)
• EPA Substance Registry System: batrachotoxinin A(19457-37-5)

Safety Data

• RIDADR: 3172
• HazardClass: 6.1(b)
• PackingGroup: III
• Hazardous Substances Data: 19457-37-5(Hazardous Substances Data)

Usage

Description

Batrachotoxinin A is an isomeric component of batrachotoxin, which is the strongest neurotoxin found among venoms. It is a steroidal alkaloid with significant toxicity, being as potent as strychnine. Batrachotoxinin A is derived from the poison dart frog native to Colombia, and its structure has been well-defined. When synthesized, it has the potential to be utilized in the medical field due to its unique properties.

Uses

Used in Pharmaceutical Industry:
Batrachotoxinin A is used as a research compound for its potent neurotoxin properties. It aids in the study of ion channels and the development of drugs targeting neurological disorders. The compound's high toxicity and specificity make it a valuable tool in understanding the mechanisms of nerve cell function and potential therapeutic applications.
Used in Venom Research:
Batrachotoxinin A is utilized as a key component in the study of venom composition and its effects on the nervous system. This research can lead to the development of new treatments for various conditions, including pain management and the treatment of neurological diseases.
Used in Drug Development:
Due to its potent neurotoxin properties, batrachotoxinin A is used as a starting point for the development of new drugs with targeted applications in neurology and pain management. Its unique structure and mode of action can provide insights into the design of more effective and safer medications.

InChI:InChI=1/C24H35NO5/c1-15(26)17-6-7-23-18-5-4-16-12-22(28)9-8-20(16,2)24(18,30-22)19(27)13-21(17,23)14-25(3)10-11-29-23/h5-6,15-16,19,26-28H,4,7-14H2,1-3H3/t15?,16-,19-,20+,21?,22+,23?,24?/m1/s1

Upstream product

• 23509-16-2 [³H]batrachotoxin 
• 39023-97-7 3α,9-epoxy-3β-methoxy-25-methyl-(5β)-14β,13-[1]oxa[4]azapentano-18-nor-pregna-7,16-diene-11α,20α_F-diol 

Downstream Products

• 23509-23-1 Batrachotoxinin A-20-(5-acetyl-2,4-dimethyl-pyrrol-3-carboxylat) 
• 23509-24-2 Batrachotoxinin A-20-(1,2,4,5-tetramethyl-pyrrol-3-carboxylat) 
• 23509-22-0 Batrachotoxinin A-20-(5-ethyl-2,4-dimethyl-pyrrol-3-carboxylat) 
• 23509-16-2 [³H]batrachotoxin 
• 23756-88-9 Batrachotoxinin A-20-(2,5-dimethyl-pyrrol-3-carboxylat) 
• 19457-36-4 20α_F-(4-bromo-benzoyloxy)-3,9-epoxy-25-methyl-(5β)-14β,13-[1]oxa[4]azapentano-18-nor-pregna-7,16-diene-3β,11α-diol 
• 23509-21-9 Batrachotoxinin A-20-(2,4,5-trimethyl-pyrrol-3-carboxylat) 

Relevant articles and documents

Steroids and sex hormones. Partial synthesis of batrachotoxinin A.

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Partial synthesis of batrachotoxin A

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