194736-58-8

Basic information

• Product Name: L-FDAA-N-methyl-Phe
• Synonyms: L-FDAA-N-methyl-Phe
• CAS NO: 194736-58-8
• Molecular Weight: 431.405
• Mol File: 194736-58-8.mol
• Article Data: 15

Chemical Properties

• CAS DataBase Reference: L-FDAA-N-methyl-Phe(CAS DataBase Reference)
• NIST Chemistry Reference: L-FDAA-N-methyl-Phe(194736-58-8)
• EPA Substance Registry System: L-FDAA-N-methyl-Phe(194736-58-8)

Safety Data

• Hazardous Substances Data: 194736-58-8(Hazardous Substances Data)

Upstream product

• 95713-52-3 N-(2,4-dinitro-5-fluorophenyl)-L-alaninamide 
• 2566-35-0 N-methylphenylalanine 
• 1070777-03-5 N-methyl-((S)-azepan-2-one-3-ylamino-(S)-oxo-3-phenylpropan-2-yl)dec-9-enamide 
• 37553-65-4 Boc-N-Me-Phe-OH 
• 13734-34-4 N-tert-butoxycarbonyl-L-phenylalanine 
• 1377420-73-9 cordyheptapeptides C 
• 2566-30-5 N-Methyl-L-phenylalanine 
• 1356174-93-0 persipeptide B 
• 1356174-91-8 persipeptide A 
• 1259395-27-1 micropeptin MM₉₁₆ 
• 1259395-26-0 micropeptin MM₈₅₀ 

Relevant articles and documents

Structural revision and absolute configuration of lateritin

'Lateritin' (1), a morpholine-2,5-dione (depsipeptide), was reinvestigated for its structure and absolute configuration. On the basis of thorough 1D and 2D NMR and mass spectrometrical analyses, the structure of 1 was revised to be identical with beauvericin (8) and confirmed that beauvericin (8) is the trimeric lactone of 'lateritin' (1). The absolute configuration was determined by acidic hydrolysis, followed by application of Marfey's method, menthyl ester derivatization, and GC-MS analysis. In addition, the specific optical rotation values of the hydrolysis products were compared with those of available standards.

Persipeptides A and B, two cyclic peptides from Streptomyces sp. UTMC 1154

Two new N-methylated cyclopeptides, persipeptide A (1) and B (2), have been isolated from Streptomyces sp. UTMC1154. Their structures were established using 1D and 2D NMR experiments. 2D TOCSY experiments were applied to identify the amino acid residues, while HMBC correlations were used to determine their sequence. According to Marfey's method, all amino acids had the l-configuration. The two cyclic peptides had the same ring size and amino acid composition, but differed in their sequence; they did not show activity against the tested bacteria, fungi and algae. Molecular identification experiments placed the strain in the genus Streptomyces closely related to Streptomyces coerulescens DSM40146T (99.45%) and Streptomyces varsoviensis DSM40346T (99.25%).

Stereocalpin B, a New Cyclic Depsipeptide from the Antarctic Lichen Ramalina terebrata

Stereocalpin B, a new cyclic depsipeptide (1), and a new dibenzofuran derivative (3), were isolated from the Antarctic lichen, Ramalina terebrata (Ramalinaceae), along with a known cyclic depsipeptide (2). The structures of new compounds were characterized by comprehensive spectrometric analyses; high-resolution fast atom bombardment mass spectrometry (HR-FABMS) and liquid chromatography-tandem mass spectrometry (LC-MS/MS). Stereocalpin B (1) existed in a rotameric equilibrium, which was confirmed using nuclear Overhauser effect spectroscopy (NO-ESY)/exchange spectroscopy (EXSY) spectrum. Absolute configurations of the amino acid units in 1 were assigned using the advanced Marfey’s method and subsequent NOESY analysis of the 5-hydroxy-2,4-dimethyl-3-oxo-decanoic acid residue confirmed the complete stereochemistry of 1. Compounds 1-3 exhibited moderate antimicrobial activities against E. coli, with the IC50 values ranging from 18?30 μg/mL. Compound 2 exhibited cell growth inhibition against HCT116 cell lines, with the IC50 value of 20 ± 1.20 μM, and compounds 1 and 2 also showed potent anti-inflammatory activities against lipopolysaccharide (LPS)-induced RAW264.7 macrophages with the IC50 values ranging from 5?7 μM.

Auyuittuqamides A-D, Cyclic Decapeptides from Sesquicillium microsporum RKAG 186 Isolated from Frobisher Bay Sediment

Four new cyclic decapeptides, auyuittuqamides A-D (1-4), were obtained from Sesquicillium microsporum RKAG 186 obtained from marine sediment collected from the intertidal zone of Frobisher Bay, Nunavut, Canada. The structures of the compounds were elucida

Polyketides and nitrogenous metabolites from the endophytic fungus Phomopsis sp. D15a2a

Three new polyketides, phomopones A?C (1–3), one new cyclic tetrapeptide, 18-hydroxydihydrotentoxin (4), and a new amide, 6-hydroxyenamidin (5) together with a known derivative, enamindin (6) were obtained from the endophytic fungus Phomopsis sp. D15a2a i