19514-06-8

Basic information

• Product Name: α-(3-Chlorophenoxy)acetophenone
• Synonyms: α-(3-Chlorophenoxy)acetophenone
• CAS NO: 19514-06-8
• Molecular Weight: 246.693
• Mol File: 19514-06-8.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: α-(3-Chlorophenoxy)acetophenone(CAS DataBase Reference)
• NIST Chemistry Reference: α-(3-Chlorophenoxy)acetophenone(19514-06-8)
• EPA Substance Registry System: α-(3-Chlorophenoxy)acetophenone(19514-06-8)

Safety Data

• Hazardous Substances Data: 19514-06-8(Hazardous Substances Data)

Upstream product

• 108-43-0 3-monochlorophenol 
• 70-11-1 α-bromoacetophenone 
• 98-86-2 acetophenone 

Downstream Products

• 1408323-54-5 C₁₄H₁₂ClNO₂ 
• 108-43-0 3-monochlorophenol 
• 50781-28-7 2-oxo-2-phenyl-ethyl 
• 27798-43-2 2-(3-chlorophenyl)-1-phenylethanone 
• 54560-44-0 3-chlorophenoxyl radical 
• 98-86-2 acetophenone 

Relevant articles and documents

Synthesis and in vitro anti-Toxoplasma gondii activity of a new series of aryloxyacetophenone thiosemicarbazones

Abstract: A new series of aryloxyacetophenone thiosemicarbazones 4a–q have been synthesized as anti-Toxoplasma gondii agents. All compounds showed significant inhibitory activity against T. gondii-infected cells (IC50 values 1.09–25.19?μg/mL). The 4-fluorophenoxy derivative (4l) was the most potent compound with the highest selectivity toward host cells (SI = 19), being better than standard drug pyrimethamine. SAR study indicated that the concurrence of proper substituents on both aryl ring of phenoxyacetophenone is important for potency and safety profile. Further in vitro experiments with the representative compounds 4l and 4p revealed that these compounds at the concentration of 5?μg/mL can significantly reduce the viability of T. gondii tachyzoites, as well as their infectivity rate and intracellular proliferation, comparable to those of pyrimethamine. Graphic abstract: [Figure not available: see fulltext.]