195299-15-1

Basic information

• Product Name: 2-cyano-5-oxazolopyrrolidine
• CAS NO: 195299-15-1
• Molecular Weight: 214.267
• Mol File: 195299-15-1.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: 2-cyano-5-oxazolopyrrolidine(CAS DataBase Reference)
• NIST Chemistry Reference: 2-cyano-5-oxazolopyrrolidine(195299-15-1)
• EPA Substance Registry System: 2-cyano-5-oxazolopyrrolidine(195299-15-1)

Safety Data

• Hazardous Substances Data: 195299-15-1(Hazardous Substances Data)

Upstream product

• 56613-80-0 D-2-phenylglycinol 
• 116127-24-3 (2R,5R)-1-((R)-2-Hydroxy-1-phenyl-ethyl)-pyrrolidine-2,5-dicarbonitrile 
• 111998-65-3 (2R,5S)-1-((R)-2-Hydroxy-1-phenyl-ethyl)-pyrrolidine-2,5-dicarbonitrile 
• 692-29-5 Succinic semialdehyde 
• 151-50-8 potassium cyanide 
• 65032-54-4 3-bromopropanal 
• 111980-33-7 (-)-N-cyanomethylphenylglycinol 
• 696-59-3 cis,trans-2,5-dimethoxytetrahydrofuran 

Downstream Products

• 111964-18-2 (3R,5S,7aS)-5-Heptyl-3-phenyl-hexahydro-pyrrolo[2,1-b]oxazole 
• 112020-15-2 (R)-2-((2R,5S)-2-Butyl-5-heptyl-pyrrolidin-1-yl)-2-phenyl-ethanol 
• 111964-19-3 (R)-2-((2S,5S)-2-Butyl-5-heptyl-pyrrolidin-1-yl)-2-phenyl-ethanol 
• 116505-91-0 (R)-2-{(2S,5R)-2-Heptyl-5-[2-(2-methyl-[1,3]dioxolan-2-yl)-ethyl]-pyrrolidin-1-yl}-2-phenyl-ethanol 
• 116561-38-7 (R)-2-{(2R,5R)-2-Heptyl-5-[2-(2-methyl-[1,3]dioxolan-2-yl)-ethyl]-pyrrolidin-1-yl}-2-phenyl-ethanol 
• 116505-90-9 (3R,5R,7aS)-5-[2-(2-Methyl-[1,3]dioxolan-2-yl)-ethyl]-3-phenyl-hexahydro-pyrrolo[2,1-b]oxazole 
• 119988-06-6 (R)-2-((2S,5S)-2-Ethyl-5-heptyl-pyrrolidin-1-yl)-2-phenyl-ethanol 
• 120054-52-6 (R)-2-((2R,5S)-2-Ethyl-5-heptyl-pyrrolidin-1-yl)-2-phenyl-ethanol 
• 120054-51-5 (R)-2-((2S,5R)-2-Ethyl-5-heptyl-pyrrolidin-1-yl)-2-phenyl-ethanol 
• 119988-05-5 (3R,5S,7aS)-5-Ethyl-3-phenyl-hexahydro-pyrrolo[2,1-b]oxazole 
• 195299-16-2 (3R,7aS)-5-(2,2-Diethoxy-ethyl)-3-phenyl-hexahydro-pyrrolo[2,1-b]oxazole-5-carbonitrile 
• 95587-05-6 cis-2-heptyl-5-butylpyrrolidine 
• 95587-14-7 (+)-(S)-trans-2-heptyl-5-butylpyrrolidine 
• 457890-62-9 (3R,7aS)-5-[2-(2-Methyl-[1,3]dioxolan-2-yl)-ethyl]-3-phenyl-hexahydro-pyrrolo[2,1-b]oxazole-5-carbonitrile 

Relevant articles and documents

ASYMMETRIC SYNTHESIS XII: STEREOCONTROLLED ELECTROPHILIC-NUCLEOPHILIC α,α'-SUBSTITUTION OF THE PYRROLIDINE RING.

The synthesis of 2-cyano-5-oxazolopyrrolidine 3, a chiral pyrrolidine synthon, is described.Conditions were established that permitted sequential chemoselective reactions at the C-2 aminonitrile (electrophilic substitution) and at the C-5 aminoether (nucl

ASYMMETRIC SYNTHESIS XI : A SHORT SYNTHESIS OF THE CHIRAL PYRROLIDINE SYNTHON, 2-CYANO-5-OXAZOLOPYRROLIDINE

The Robinson-Schopf condensation of dimethoxytetrahydrofuran with R(-)phenylglycinol in the presence of KCN followed by reflux in ethanol leads to the formation of 2-cyano-5-oxazolopyrrolidine 1b in 52percent overall yield.