19541-99-2

Basic information

• Product Name: 1-HYDROXYMETHYLBENZIMIDAZOLE
• Synonyms: benzimidazol-1-ylmethanol;N-Hydroxymethylbenzimidazole;1H-BENZO[D]IMIDAZOL-1-YLMETHANOL;1-HYDROXYMETHYLBENZIMIDAZOLE;1H-Benzimidazole-1-methanol(9CI);1-benzimidazolylmethanol
• CAS NO: 19541-99-2
• Molecular Formula: C₈H₈N₂O
• Molecular Weight: 148.16
• Product Categories: BENZIMIDAZOLE
• Mol File: 19541-99-2.mol
• Article Data: 8

Chemical Properties

• Melting Point: 141-143 °C
• Boiling Point: 321.3°Cat760mmHg
• Flash Point: 148.1°C
• Appearance: /
• Density: 1.26g/cm³
• Vapor Pressure: 0.000124mmHg at 25°C
• Refractive Index: 1.64
• Storage Temp.: 2-8°C
• PKA: 13.80±0.10(Predicted)
• CAS DataBase Reference: 1-HYDROXYMETHYLBENZIMIDAZOLE(CAS DataBase Reference)
• NIST Chemistry Reference: 1-HYDROXYMETHYLBENZIMIDAZOLE(19541-99-2)
• EPA Substance Registry System: 1-HYDROXYMETHYLBENZIMIDAZOLE(19541-99-2)

Safety Data

• HazardClass: IRRITANT
• Hazardous Substances Data: 19541-99-2(Hazardous Substances Data)

Usage

General Description

1-Hydroxymethylbenzimidazole is a chemical compound with the molecular formula C8H8N2O and a molar mass of 148.16 g/mol. It is an intermediate in the metabolism of histidine and is a potential biomarker for the presence of histidinemia, a rare metabolic disorder. 1-Hydroxymethylbenzimidazole is also used as a vitamin B6 antagonist, making it a valuable tool in studying the role of vitamin B6 in various physiological processes. In addition, it has been identified as a potential anti-cancer agent and has shown promising results in inhibiting the proliferation of cancer cells in laboratory studies. Overall, 1-Hydroxymethylbenzimidazole is a versatile compound with important roles in metabolism, vitamin research, and potential therapeutic applications in cancer treatment.

InChI:InChI=1/C8H8N2O/c11-6-10-5-9-7-3-1-2-4-8(7)10/h1-5,11H,6H2

Upstream product

• 51-17-2 benzoimidazole 
• 50-00-0 formaldehyd 

Downstream Products

• 75802-91-4 1-(Chloromethyl)-1H-benzimidazolium chloride 
• 92555-07-2 1-(4-acetylamino-benzenesulfonyl)-1H-benzoimidazole 
• 93138-12-6 1-(3-nitro-benzenesulfonyl)-benzimidazole 
• 15728-45-7 1-((4-chlorophenyl)sulfonyl)-1H-benzo[d]imidazole 
• 15728-44-6 1-(4-methyl-benzenesulfonyl)-benzimidazole 
• 304475-19-2 1‐(mesitylsulfonyl)‐1H‐benzo[d]imidazole 
• 325810-52-4 1-(2',4'-dimethylbenzenesulfonyl)benzimidazole- 
• 63873-96-1 N-benzoimidazol-1-ylmethyl-2-chloro-aniline 
• 63873-97-2 N-benzoimidazol-1-ylmethyl-3-chloro-aniline 
• 63873-92-7 N-benzoimidazol-1-ylmethyl-aniline 
• 63873-98-3 N-benzoimidazol-1-ylmethyl-4-chloro-aniline 

Relevant articles and documents

Benzazoles 5*. synthesis and arylsulfonylation of 1-hydroxymethylbenzimidazole

1-Hydroxymethylbenzimidazole was synthesized by the reaction of benzimidazole with formaldehyde. Arylsulfonylation of the former in the presence of triethylamine occurred anomalously with deformylation to give 1-arylsulfonylbenzimidazoles in place of the

Pyrazolopyrimidines as therapeutic agents

The present invention is directed to pyrazolopyrimidine derivatives of formula (I) wherein the substituents are defined herein, which are useful as kinase inhibitors and as such are useful for affecting angiogenesis and diseases and conditions associated with angiogenesis.

Application of ultrasound irradiation for the reactions of N-hydroxymethylation

A convenient and high yield method for the N-hydroxymethylation of substituted phthalimide and benzimidazole under ultrasound irradiation is reported.