19579-63-6

Basic information

• Product Name: 3-hydroxy-3-(1-oxo-1,2,3,4-tetrahydronaphthalen-2-yl)-1,3-dihydro-2H-indol-2-one
• Synonyms: 2H-indol-2-one, 1,3-dihydro-3-hydroxy-3-(1,2,3,4-tetrahydro-1-oxo-2-naphthalenyl)-
• CAS NO: 19579-63-6
• Molecular Formula: C₁₈H₁₅NO₃
• Molecular Weight: 293.3166
• Mol File: 19579-63-6.mol
• Article Data: 5

Chemical Properties

• Boiling Point: 564.3°C at 760 mmHg
• Flash Point: 295.1°C
• Density: 1.377g/cm³
• Vapor Pressure: 1.44E-13mmHg at 25°C
• Refractive Index: 1.675
• CAS DataBase Reference: 3-hydroxy-3-(1-oxo-1,2,3,4-tetrahydronaphthalen-2-yl)-1,3-dihydro-2H-indol-2-one(CAS DataBase Reference)
• NIST Chemistry Reference: 3-hydroxy-3-(1-oxo-1,2,3,4-tetrahydronaphthalen-2-yl)-1,3-dihydro-2H-indol-2-one(19579-63-6)
• EPA Substance Registry System: 3-hydroxy-3-(1-oxo-1,2,3,4-tetrahydronaphthalen-2-yl)-1,3-dihydro-2H-indol-2-one(19579-63-6)

Safety Data

• Hazardous Substances Data: 19579-63-6(Hazardous Substances Data)

Upstream product

• 91-56-5 indole-2,3-dione 
• 38858-72-9 1-trimethylsiloxy-3,4-dihydronaphthalene 
• 59-48-3 2-oxoindole 
• 529-34-0 3,4-dihydronaphthalene-1(2H)-one 

Relevant articles and documents

Chiral Silver Alkoxide Catalyzed Asymmetric Aldol Reaction of Alkenyl Esters with Isatins

A catalytic enantioselective aldol reaction of alkenyl esters with isatins was achieved using a DM-BINAP·AgOTf complex as the chiral precatalyst and N, N -diisopropylethylamine as the base precatalyst in the presence of methanol or 2,2,2-trifluoroethanol.

C U 2O-Catalyzed C(SP 3)-H/C(SP 3)-H Cross-Coupling Using TEMPO: Synthesis of 3-(2-Oxoalkyl)-3-hydroxyoxindoles

A simple, convenient, and efficient oxidative cross-coupling reaction of oxindoles with ketones toward a variety of 3-(2-oxoalkyl)-3-hydroxyoxindoles in moderate to excellent yields has been developed. This transformation proceeds via a tandem oxidative cross-coupling by using 2,2,6,6-tetramethylpiperidine N-oxyl (TEMPO) in air as an environmentally benign oxidant. This methodology provides an alternative approach for the direct generation of all-carbon quaternary centers at the C3 position of oxindoles.

Potential Anticonvulsants. III. The Condensation of Isatin with Cyclic Ketones

Isatin has been condensed with a series of cyclic ketones to give 3-substituted-3-hydroxyoxindoles as potential anticonvulsants.