19658-64-1

Basic information

• Product Name: ETHYL 6-HYDROXY-[1,3]DIOXOLO[4,5-G]QUINOLINE-7-CARBOXYLATE
• Synonyms: ETHYL 6-HYDROXY-[1,3]DIOXOLO[4,5-G]QUINOLINE-7-CARBOXYLATE
• CAS NO: 19658-64-1
• Molecular Formula: C13H11NO5
• Molecular Weight: 261.23
• Mol File: 19658-64-1.mol
• Article Data: 1

Chemical Properties

• Melting Point: 186-188 °C
• Boiling Point: 469.9±45.0 °C(Predicted)
• Appearance: /
• Density: 1.409±0.06 g/cm3(Predicted)
• PKA: 10.50±0.40(Predicted)
• CAS DataBase Reference: ETHYL 6-HYDROXY-[1,3]DIOXOLO[4,5-G]QUINOLINE-7-CARBOXYLATE(CAS DataBase Reference)
• NIST Chemistry Reference: ETHYL 6-HYDROXY-[1,3]DIOXOLO[4,5-G]QUINOLINE-7-CARBOXYLATE(19658-64-1)
• EPA Substance Registry System: ETHYL 6-HYDROXY-[1,3]DIOXOLO[4,5-G]QUINOLINE-7-CARBOXYLATE(19658-64-1)

Safety Data

• Hazardous Substances Data: 19658-64-1(Hazardous Substances Data)

Upstream product

• 712-97-0 6-nitro-1,3-benzodioxole-5-carbaldehyde 
• 120-57-0 piperonal 
• 105-53-3 diethyl malonate 
• 23126-68-3 6-amino-benzo[1,3]dioxole-5-carbaldehyde 

Relevant articles and documents

Synthesis of new quinoline-piperonal hybrids as potential drugs against Alzheimer’s disease

Six quinoline-piperonal hybrids were synthesized and evaluated as potential drugs against Alzheimer’s disease (AD). Theoretical analysis of the pharmacokinetic and toxicological properties of the compounds suggest that they present good oral bio-availability and are also capable of penetrating the blood–brain barrier, qualifying as leads for new drugs against AD. Evaluation of their inhibitory capacity against acetyl-and butyrilcholinesterases (AChE and BChE) through Ellmann’s test showed that three compounds present promising results with one of them being capable of inhibiting both enzymes. Further docking studies of the six compounds synthesized helped to elucidate the main interactions that may be responsible for the inhibitory activities observed.