196601-67-9 Usage
Description
(R)-2-N-acetamido-3-methoxypropionic acid, also known as MAPA, is a compound that belongs to the class of organic compounds known as alpha amino acid esters and is a derivative of L-cysteine. It is characterized by its ability to form stable amide bonds, which makes it a valuable tool in chemical synthesis. MAPA is recognized for its potential use in the synthesis of biologically active molecules and has been studied for its applications in drug delivery systems and as a building block for designing bioactive compounds.
Uses
Used in Pharmaceutical Synthesis:
(R)-2-N-acetamido-3-methoxypropionic acid is used as a building block for the synthesis of biologically active molecules, particularly in the production of peptide-based drugs. Its ability to form stable amide bonds makes it a crucial component in the development of pharmaceuticals.
Used in Drug Delivery Systems:
In the pharmaceutical industry, (R)-2-N-acetamido-3-methoxypropionic acid is used as a component in the design of drug delivery systems. Its properties contribute to the enhancement of drug bioavailability and the overall effectiveness of therapeutic treatments.
Used in Chemical Synthesis:
(R)-2-N-acetamido-3-methoxypropionic acid is utilized as a valuable tool in chemical synthesis due to its capacity to form stable amide bonds, which are essential in creating a variety of compounds with potential applications in various fields.
Check Digit Verification of cas no
The CAS Registry Mumber 196601-67-9 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,9,6,6,0 and 1 respectively; the second part has 2 digits, 6 and 7 respectively.
Calculate Digit Verification of CAS Registry Number 196601-67:
(8*1)+(7*9)+(6*6)+(5*6)+(4*0)+(3*1)+(2*6)+(1*7)=159
159 % 10 = 9
So 196601-67-9 is a valid CAS Registry Number.
196601-67-9Relevant articles and documents
A synthesis scheme for preparing method
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Paragraph 0023; 0046; 0047; 0059, (2017/07/19)
The invention provides a preparation method of lacosamide, which comprises following steps: (A) performing a reaction between D-serine and acetic anhydride to generate an intermediate product N,O-diacetyl-D-serine; (B) performing methylation to the N,O-diacetyl-D-serine to obtain N-acetyl-D-serine methyl ether; (C) carrying out a reaction to the N-acetyl-D-serine methyl ether with benzylamine to obtain (R)-2-acetamido-N-benzyl-3-methoxyl propionamide. The preparation method is short in reaction route, can avoid racemization, and is high in yield and purity of a reaction product.
METHOD FOR PREPARING LACOSAMIDE
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Paragraph 0032; 0033, (2016/12/01)
The present invention provides a novel method for preparing lacosamide with high chiral purity from D-serine. The method of the present invention can obtain lacosamide with high chiral purity in a high yield through a simple and environmentally-friendly process and thus can be easily applied to mass production.
Total synthesis of lacosamide
Stecko, Sebastian
, p. 6342 - 6346 (2014/07/21)
Total synthesis of anticonvulsant amino acid, lacosamide, is reported. The key step is stereospecific allyl cyanate-to-isocyanate rearrangement, which proceeds with chirality transfer. The enantiopure starting material for the rearrangement step was accessed from ethyl l-lactate.
