19666-76-3

Basic information

• Product Name: Panaxadiol
• Synonyms: PANAXADIOL;DAMMARANE-3BETA,12BETA-DIOL;PANAXADIOL 98.0% BY HPLC;(20R)-20,25-Epoxy-5α-dammarane-3β,12β-diol;(20R)-Panaxadiol;PALMITIC ACID METHYLESTER 99%(RG) (SEE METHYL PALMITATE);Panaxadiol ,98%;Panaxaidol
• CAS NO: 19666-76-3
• Molecular Formula: C30H52O3
• Molecular Weight: 460.73
• Product Categories: Steroids;Ginseng series;chemical reagent;pharmaceutical intermediate;phytochemical;reference standards from Chinese medicinal herbs (TCM).;standardized herbal extract;Inhibitors
• Mol File: 19666-76-3.mol
• Article Data: 1

Chemical Properties

• Melting Point: 250℃
• Boiling Point: 531.3 °C at 760 mmHg
• Flash Point: 275.1 °C
• Appearance: /
• Density: 1.025 g/cm³
• Vapor Pressure: 1.65E-13mmHg at 25°C
• Refractive Index: 1.515
• Storage Temp.: Refrigerator
• Solubility: Chloroform (Slightly), Ethyl Acetate (Slightly)
• PKA: 14.82±0.70(Predicted)
• CAS DataBase Reference: Panaxadiol(CAS DataBase Reference)
• NIST Chemistry Reference: Panaxadiol(19666-76-3)
• EPA Substance Registry System: Panaxadiol(19666-76-3)

Safety Data

• Safety Statements: 24/25
• Hazardous Substances Data: 19666-76-3(Hazardous Substances Data)

Usage

Chemical Properties

White solid

Uses

Panaxadiol is the purified sapogenin of ginseng saponins, which exhibits anti-tumor activity. Research has shown Panaxadiol exhibited enhancing activity towards human colorectal cancer cells.

InChI:InChI=1/C30H52O3/c1-25(2)13-9-14-30(8,33-25)19-10-16-29(7)24(19)20(31)18-22-27(5)15-12-23(32)26(3,4)21(27)11-17-28(22,29)6/h19-24,31-32H,9-18H2,1-8H3

Related news

Sensitive Determination of Panaxadiol (cas 19666-76-3) Using Rhodamine B as Sensitizing Derivatization Reagent by Ultrahigh Performance Liquid Chromatography Triple Quadrupole Mass Spectrometry09/09/2019

Commercial Rhodamine B was first reported as a derivatization reagent labeling hydroxyl compound for mass spectrometry sensitization. In virtue of the strategy of ultrasonic-assisted dispersive liquid-liquid microextraction (UA-DLLME) combined with Rhodamine B derivatization, a new method of ult...detailed

Malignant HematopoiesisThe effects of Panaxadiol (cas 19666-76-3) saponins on megakaryocytic maturation and immune function in a mouse model of immune thrombocytopenia09/08/2019

We have identified a biologically active component, panaxadiol saponins component (PDS-C), from Chinese ginseng herb extract. Panaxadiol saponins component contains five ginsenoside monomers with total purity of 92.44%. In this study, the BALB/c mouse model with immune thrombocytopenia (ITP) was...detailed

Original articleEfficient synthesis of Panaxadiol (cas 19666-76-3) derivatives using continuous-flow microreactor and evaluation of anti-tumor activity09/04/2019

An efficient method has been developed for the synthesis of a series of (20R)-panaxadiol derivatives (4a–w) using a continuous-flow microreactor. The antitumor activities of the newly synthesized compounds were evaluated in vitro in two human prostate adenocarcinoma tumor cell lines (i.e., PC-3...detailed

Original articleSynthesis and anti-tumor evaluation of Panaxadiol (cas 19666-76-3) derivatives09/02/2019

A series of panaxadiol derivatives have been synthesized by the simple acylation of the 3-hydroxy group of panaxadiol. The anti-tumor activities of the synthesized compounds were evaluated against a panel of human tumor cell lines by the standard MTT assay. Compounds 2, 11, 12, 13, 14, 15 and 16...detailed

Synthesis and anti-tumor evaluation of Panaxadiol (cas 19666-76-3) halogen-derivatives09/01/2019

In the current work, 13 novel panaxadiol (PD) derivatives were synthesized by reacting with chloroacetyl chloride and bromoacetyl bromide. Their in vitro antitumor activities were evaluated on three human tumor cell lines (HCT-116, BGC-823, SW-480) and three normal cells (human gastric epithelia...detailed

Panaxadiol (cas 19666-76-3) inhibits synaptic dysfunction in Alzheimer's disease and targets the Fyn protein in APP/PS1 mice and APP-SH-SY5Y cells08/31/2019

AimAlzheimer's disease (AD), a neurodegenerative disease, is characterized by memory loss and synaptic damage. Up to now, there are limited drugs to cure or delay the state of this illness. Recently, the Fyn tyrosine kinase is implicated in AD pathology triggered by synaptic damage. Thus, F...detailed

Relevant articles and documents

Chemical studies on the oriental plant drugs. XVII. The prosapogenin of the ginseng saponins (ginsenosides-Rb1, -Rb2, and -Rc).

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