19689-87-3 Usage
Description
(2-methoxy-6-nitrophenyl)methanol, also known as Linsitinib, is a chemical compound that features a nitrophenyl group and a methanol group. It serves as a research tool and a building block in organic synthesis, with a focus on cancer research and treatment.
Used in Pharmaceutical Research:
(2-methoxy-6-nitrophenyl)methanol is used as a research tool for its potential application in cancer research and treatment. It is recognized for its ability to inhibit insulin-like growth factor 1 (IGF-1) and insulin receptor signaling, which are implicated in tumor cell growth and proliferation.
Used in Cancer Treatment Development:
In the field of oncology, (2-methoxy-6-nitrophenyl)methanol is used as a potent inhibitor of IGF-1 and insulin receptor signaling for its potential to inhibit tumor cell growth and proliferation. This makes it a promising candidate for the development of targeted cancer therapies.
Used in Organic Synthesis:
(2-methoxy-6-nitrophenyl)methanol is also used as a building block in organic synthesis, where its unique chemical structure and properties may contribute to the design and development of novel anti-cancer drugs.
Check Digit Verification of cas no
The CAS Registry Mumber 19689-87-3 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 1,9,6,8 and 9 respectively; the second part has 2 digits, 8 and 7 respectively.
Calculate Digit Verification of CAS Registry Number 19689-87:
(7*1)+(6*9)+(5*6)+(4*8)+(3*9)+(2*8)+(1*7)=173
173 % 10 = 3
So 19689-87-3 is a valid CAS Registry Number.
19689-87-3Relevant articles and documents
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Wani,M.C.,Wall,M.E.
, p. 1364 - 1367 (1969)
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Synthesis of 7,8-disubstituted benzolactam-V8 and its binding to protein kinase C
Ma, Dawei,Zhang, Tao,Wang, Guoqiang,Kozikowski, Alan P.,Lewin, Nancy E.,Blumberg, Peter M.
, p. 99 - 101 (2007/10/03)
7-methoxy-8-decynyl-benzolactam-V8 4 is synthesized using a catalytic asymmetric alkylation reaction as a key step. This compound shows potent activity to three PKC isozymes tested (Ki = 45.6, 91.1, and 121.3 nM to PKCα, δ, and ε, respectively), indicating that introduction of a suitable substituent at the 7-position of 8-decynyl-benzolactam-V8 only slightly reduces the PKC binding affinity.
