1970-52-1

Basic information

• Product Name: Propanamide, 2-bromo-N-(4-chlorophenyl)-2-methyl-
• CAS NO: 1970-52-1
• Molecular Formula: C10H11BrClNO
• Molecular Weight: 276.56
• Mol File: 1970-52-1.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: Propanamide, 2-bromo-N-(4-chlorophenyl)-2-methyl-(CAS DataBase Reference)
• NIST Chemistry Reference: Propanamide, 2-bromo-N-(4-chlorophenyl)-2-methyl-(1970-52-1)
• EPA Substance Registry System: Propanamide, 2-bromo-N-(4-chlorophenyl)-2-methyl-(1970-52-1)

Safety Data

• Hazardous Substances Data: 1970-52-1(Hazardous Substances Data)

Upstream product

• 20769-85-1 2-bromoisobutyric acid bromide 
• 106-47-8 4-chloro-aniline 
• 7160-05-6 N-(4-chlorophenyl)-2,2-dimethylacetamide 

Downstream Products

• 35844-05-4 p-chloro-α-nitroisobutyranilide 
• 2918-77-6 N-(p-chlorophenyl)methacrylamide 
• 7160-05-6 N-(4-chlorophenyl)-2,2-dimethylacetamide 
• 69336-98-7 3(4'-chloroanilino)2,2-dimethyl-3-oxo-propanoic acid methyl ester 

Relevant articles and documents

Bromo-nitro substitution on a tertiary α carbon - A previously uncharacterized facet of the Kornblum substitution

Sodium nitrite in dimethylformamide substitutes nitro for bromine alpha to an amide carbonyl in high yield at a tertiary site. Hammett plots show a strongly positive ρ value (+0.67), indicating a negatively-charged transition state, in contrast to the typical SN1/SN2 mechanism domain for Kornblum substitutions. 2015

Synthesis and evaluation of the local anesthetic activity of a series of aliphatic amino acid anilides

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