197006-08-9

Basic information

• Product Name: (R)-5-[(2-t-butoxycarbonylamino-3-benzyloxy)-propyl]-2,2-dimethyl-1,3-dioxane-4,6-dione
• CAS NO: 197006-08-9
• Molecular Weight: 407.464
• Mol File: 197006-08-9.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: (R)-5-[(2-t-butoxycarbonylamino-3-benzyloxy)-propyl]-2,2-dimethyl-1,3-dioxane-4,6-dione(CAS DataBase Reference)
• NIST Chemistry Reference: (R)-5-[(2-t-butoxycarbonylamino-3-benzyloxy)-propyl]-2,2-dimethyl-1,3-dioxane-4,6-dione(197006-08-9)
• EPA Substance Registry System: (R)-5-[(2-t-butoxycarbonylamino-3-benzyloxy)-propyl]-2,2-dimethyl-1,3-dioxane-4,6-dione(197006-08-9)

Safety Data

• Hazardous Substances Data: 197006-08-9(Hazardous Substances Data)

Upstream product

• 23680-31-1 BOC-O-benzyl-L-serine 
• 2033-24-1 cycl-isopropylidene malonate 

Downstream Products

• 107640-69-7 (R)-N-t-butoxycarbonyl-5-benzyloxymethyl-2-pyrrolidinone 

Relevant articles and documents

Facile stereoselective synthesis of γ-substituted γ-amino acids from the corresponding α-amino acids

A facile stereoselective method for the synthesis of γ-substituted, γ-amino acids from α-amino acids was developed. The key step of the procedure is complete reduction of the keto functionality of α-amino acyl Meldrum's acid by sodium acetoxyborohydride. The resulting amino alkyl Meldrum's acid undergoes thermal decarboxylative ring closure to a 5-substituted pyrrolidinone which yields the corresponding γ-amino acid after basic hydrolysis. The overall yield of the procedure ranges from 40 to 65%.