197073-43-1

Basic information

• Product Name: BOC-4-AMINOCINNAMIC ACID
• Synonyms: BOC-4-AMINOCINNAMIC ACID
• CAS NO: 197073-43-1
• Molecular Formula: C₁₄H₁₇NO₄
• Molecular Weight: 263.29
• Mol File: 197073-43-1.mol
• Article Data: 8

Chemical Properties

• Appearance: /
• CAS DataBase Reference: BOC-4-AMINOCINNAMIC ACID(CAS DataBase Reference)
• NIST Chemistry Reference: BOC-4-AMINOCINNAMIC ACID(197073-43-1)
• EPA Substance Registry System: BOC-4-AMINOCINNAMIC ACID(197073-43-1)

Safety Data

• HazardClass: IRRITANT
• Hazardous Substances Data: 197073-43-1(Hazardous Substances Data)

Upstream product

• 17570-30-8 trans-p-aminocinnamic acid 
• 1538-75-6 2,2-dimethylpropanoic anhydride 
• 79-10-7 acrylic acid 
• 6163-58-2 tris-(o-tolyl)phosphine 
• 131818-17-2 tert-butyl (4-bromophenyl)carbamate 
• 24424-99-5 di-tert-butyl dicarbonate 

Downstream Products

• 1392506-35-2 tert-butyl (4-((E)-3-(((R)-1-(((R)-1-((7-chloroquinolin-4-yl)amino)-1-oxo-4-phenylbutan-2-yl)amino)-4-methyl-1-oxopentan-2-yl)amino)-3-oxoprop-1-en-1-yl)phenyl)carbamate 
• 1041867-85-9 tert-butyl N-{4-[(E)-3-(1H-1,2,3-benzotriazole-1-yl)-3-oxo-1-propenyl]phenyl}carbamate 

Relevant articles and documents

Construction of supramolecular polymers with alternating α-, β-cyclodextrin units using conformational change induced by competitive guests

Supramolecular polymers having alternating α- and β-cyclodextrin (CD) units have been prepared by using conformational change induced by competitive guests. Although each CD unit does not form intermolecular complexes, a mixture of an α-CD derivative and a β-CD derivative formed intermolecular complexes to give supramolecular polymers having alternating CD units. This is the first example of construction of supramolecular polymers with alternating α-, β-cyclodextrin units. Copyright

Structural Fine-Tuning of Desmuramylpeptide NOD2 Agonists Defines Their in Vivo Adjuvant Activity

We report on the design, synthesis, and biological evaluation of a series of nucleotide-binding oligomerization-domain-containing protein 2 (NOD2) desmuramylpeptide agonists with improved in vitro and in vivo adjuvant properties. We identified two promising compounds: 68, a potent nanomolar in vitro NOD2 agonist, and the more lipophilic 75, which shows superior adjuvant activity in vivo. Both compounds had immunostimulatory effects on peripheral blood mononuclear cells at the protein and transcriptional levels, and augmented dendritic-cell-mediated activation of T cells, while 75 additionally enhanced the cytotoxic activity of peripheral blood mononuclear cells against malignant cells. The C18 lipophilic tail of 75 is identified as a pivotal structural element that confers in vivo adjuvant activity in conjunction with a liposomal delivery system. Accordingly, liposome-encapsulated 75 showed promising adjuvant activity in mice, surpassing that of muramyl dipeptide, while achieving a more balanced Th1/Th2 immune response, thus highlighting its potential as a vaccine adjuvant.

Preparation and synthetic applications of N-(α,β-unsaturated acyl)-α-amino acid derivatives

N-(α,β-Unsaturated acyl)-α-amino acids, amides and esters are structural motifs of many biologically active natural products. An alternate and advantageous approach for the synthesis of N-(α,β-unsaturated acyl)-α-amino acid derivatives is developed via ac