1971-46-6

Basic information

• Product Name: 1,2,3-Trimethyl-1H-indole
• Synonyms: 1,2,3-Trimethyl-1H-indole
• CAS NO: 1971-46-6
• Molecular Formula: C₁₁H₁₃N
• Molecular Weight: 159.2276
• Mol File: 1971-46-6.mol
• Article Data: 1

Chemical Properties

• Melting Point: 18°C
• Boiling Point: 304.74°C (estimate)
• Flash Point: 125.9°C
• Appearance: /
• Density: 0.9567 (estimate)
• Vapor Pressure: 0.00506mmHg at 25°C
• Refractive Index: 1.6110 (estimate)
• CAS DataBase Reference: 1,2,3-Trimethyl-1H-indole(CAS DataBase Reference)
• NIST Chemistry Reference: 1,2,3-Trimethyl-1H-indole(1971-46-6)
• EPA Substance Registry System: 1,2,3-Trimethyl-1H-indole(1971-46-6)

Safety Data

• Hazardous Substances Data: 1971-46-6(Hazardous Substances Data)

Usage

Synthesis Reference(s)

Tetrahedron Letters, 27, p. 377, 1986 DOI: 10.1016/S0040-4039(00)84023-X

InChI:InChI=1/C11H13N/c1-8-9(2)12(3)11-7-5-4-6-10(8)11/h4-7H,1-3H3

Upstream product

• 91-55-4 2,3-dimethylindole 
• 5418-63-3 1,2,3,3-tetramethyl-3H-indolium iodide 
• 2058-74-4 1-methyl-1H-indole-2,3-dione 
• 75-16-1 methylmagnesium bromide 

Downstream Products

• 1971-44-4 1,3-dimethyl-2-formylindole 
• 39581-33-4 N-(2-acetylphenyl)-N-methylacetamide 
• 5418-63-3 1,2,3,3-tetramethyl-3H-indolium iodide 
• 118-12-7 1,3,3-Trimethyl-2-methyleneindoline 

Relevant articles and documents

Facile regiospecific synthesis of 2,3-disubstituted indoles from isatins

A facile regiospecific synthesis of 2,3-disubstituted indoles from isatins has been developed. Nucleophilic addition of Grignard reagents to commercially available isatins, followed by reduction with borane, afforded an array of structurally diverse 2,3-disubstituted indoles in moderate to good yields. The method described herein represents a novel and very simple approach to synthesize various 2,3-disubstituted indoles, extremely important structural motifs in the pharmaceutical industry and medicinal chemistry. This journal is the Partner Organisations 2014.