197144-27-7Relevant articles and documents
Understanding the guanidine-like cationic moiety for optimal binding into the DNA minor groove
O'Sullivan, Patrick,Rozas, Isabel
, p. 2065 - 2073 (2014)
Based on our previous positive results with bis-guanidine-like diaromatic compounds as DNA minor groove binders, we propose a new family: bis-2-amino-1,4,5,6-tetrahydropyrimidines. According to calculated parameters, these dicationic systems would have a more suitable size and lipophilicity for binding into the minor groove than previous series. Moreover, their DFT-optimised structures and docking into an AT oligomer model show that they would bind in the minor groove with good strength and without energy penalty. Hence, we prepared compounds 4 a-c and evaluated their binding to ssDNA and poly(dA-dT)2 by thermal denaturation experiments. The results showed that 4 a (CO) and 4 d (NH) were the best DNA binders. Compared to the previous series, 4 a-d are better binders than bis-guanidiniums but poorer than bis-2-aminoimidazolinium derivatives. Moreover, circular dichroism experiments using ssDNA and poly(dA-dT)2 confirmed binding into the minor groove. Based on our computational design as well as biophysical studies, we have been able to determine that the optimal interaction of guanidine-like dications in the minor grove occurs with bis-2-aminoimidazolinium systems.
A carbazole di-aryl amines dendritic compound and its preparation method and application
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Paragraph 0075-0075, (2018/05/24)
The invention relates to a carbazole diarylamine dendritic compound as well as a preparation method and application of the carbazole diarylamine dendritic compound. According to the preparation method of the carbazole diarylamine dendritic compound, halogenated 9,9minute-spirobifluorene, a catalyst and a carbazole diarylamine compound are mixed with organic alkali; the mixture takes reaction under the inert gas protection by using xylene as a solvent; re-crystallization is performed for purification; the carbazole diarylamine dendritic compound obtained shown as the accompanying drawing is obtained. The prepared carbazole diarylamine dendritic compound has the advantages that the process and a refining method are simple and convenient; the carbazole diarylamine dendritic compound is very suitable for industrial production; better heat stability and better morphologic stability are realized; when the carbazole diarylamine dendritic compound is used as a hole-transporting material of a perovskite solar cell, higher photovoltaic conversion efficiency is realized.
A 9,9 the- [...][...] dendritic compound, preparation method and application
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Paragraph 0053-0059, (2019/02/02)
The invention relates to a dendritic compound using 9,9'-spirobifluorene as a kernel and methoxyl group substituted diarylamine as a branch compound, and the application of the dendritic compound in perovskite solar batteries, and belongs to the field of the preparation of solar battery materials. The preparation method comprises the following steps: firstly, reacting 4,4'-dibrom diphenylamine which is protected through tert-butyloxycarbonyl with 4,4'-dimethoxy diphenylamine or 4,4'-N,N'-(4,4'-dimethoxy diphenyl) diphenylamine so as to generate a branch with a protecting group, and then carrying out deprotection under the action of trifluoroacetic acid so as to generate a first-generation branch and a second-generation branch respectively; reacting the first-generation branch or the second-generation branch respectively with the bromo-9,9'-spirobifluorene compound under the action of a palladium catalyst so as to obtain a first-generation 9,9'-spirobifluorene spirofluorene dendritic compound or a second-generation 9,9'-spirobifluorene spirofluorene dendritic compound. The dendritic compound disclosed by the invention has better heat stability and solubility, is used as a hole transport material for the perovskite solar batteries, and has higher photoelectric conversion efficiency.
