19729-30-7

Basic information

• Product Name: GLY-GLY-ALA
• Synonyms: GLY-GLY-ALA;GLYCYL-GLYCYL-L-ALANINE;H-GLY-GLY-ALA-OH;Diglycylalanine;NSC 89600
• CAS NO: 19729-30-7
• Molecular Formula: C₇H₁₃N₃O₄
• Molecular Weight: 203.2
• Product Categories: Dipeptides and Tripeptides;Peptides;Tripeptides
• Mol File: 19729-30-7.mol
• Article Data: 1

Chemical Properties

• Boiling Point: 604.6 °C at 760 mmHg
• Flash Point: 319.5 °C
• Appearance: White crystalline powder
• Density: 1.314
• Vapor Pressure: 3.53E-16mmHg at 25°C
• Refractive Index: 1.517
• Storage Temp.: −20°C
• CAS DataBase Reference: GLY-GLY-ALA(CAS DataBase Reference)
• NIST Chemistry Reference: GLY-GLY-ALA(19729-30-7)
• EPA Substance Registry System: GLY-GLY-ALA(19729-30-7)

Safety Data

• WGK Germany: 3
• Hazardous Substances Data: 19729-30-7(Hazardous Substances Data)

Usage

Description

GLY-GLY-ALA, also known as a tripeptide, is a compound composed of glycine, glycine, and L-alanine residues joined in sequence. It is a solid with unique chemical properties that make it suitable for various applications across different industries.

Uses

Used in Pharmaceutical Industry:
GLY-GLY-ALA is used as a pharmaceutical ingredient for its potential therapeutic effects. Its unique structure and properties allow it to interact with biological systems, making it a promising candidate for the development of new drugs and therapies.
Used in Cosmetic Industry:
GLY-GLY-ALA is used as an active ingredient in cosmetic products for its potential skin benefits. Its ability to interact with biological systems can contribute to improved skin health and appearance.
Used in Food Industry:
GLY-GLY-ALA is used as a food additive for its potential nutritional and functional benefits. Its unique properties can enhance the taste, texture, and shelf life of various food products.
Used in Research and Development:
GLY-GLY-ALA is used as a research tool for studying the properties and interactions of peptides and amino acids. Its unique structure and properties make it an important compound for understanding the fundamentals of peptide chemistry and biology.

InChI:InChI=1/C7H13N3O4/c1-4(7(13)14)10-6(12)3-9-5(11)2-8/h4H,2-3,8H2,1H3,(H,9,11)(H,10,12)(H,13,14)/t4-/m0/s1

Upstream product

• 3695-73-6 glycyl-L-alanine 
• 886455-88-5 N-(N-chloroacetyl-glycyl)-L-alanine 

Downstream Products

• 1156540-92-9 (S)-2-(2-(2-((1R,2R)-2-phenylcyclopropanecarboxamido)acetamido)acetamido)propanoic acid 
• 56-41-7 L-alanin 
• 687-69-4 alanylglycine 
• 3695-73-6 glycyl-L-alanine 
• 56-40-6 glycine 
• 4526-77-6 (S)-3-methyl-2,5-piperazinedione 
• 100047-94-7 Gly-Gly-Ala-OMe 

Relevant articles and documents

Effect of hydroxide ion on the kinetics of triethylenetetramine displacement of tripeptides from copper(II) complexes

Triethylenetetramine (trien) reacts rapidly with doubly deprotonated (tripeptido)cuprate(II) complexes, Cu(H-2L)-, to give Cu(trien)2+ and the free tripeptide, where L = GAG, GGA, GAibG, and Aib3 (G, glycyl; A, L-alanyl; Aib, α-aminoisobutyryl). The reactions are first order in each reactant, and the second-order rate constants (M-1 s-1, 25.0°C, μ = 1.0 M) decrease greatly with the number of methyl groups in the second and third residues: 8.4 × 104 (GAG), 7.9 × 104 (GGA), 43 (GAibG), and 0.13 (Aib3). When L is GAG, GGA, and GAibG, the values of the second-order rate constants (for [trien]T and [Cu(H-2L)-]T) increase above p[H+] 9 and reach maximum values at p[H+] 10.7 ± 0.7. The increase occurs because trien and Htrien+ are more reactive than H2trien2+. The rate constants decrease in higher base due to the formation of Cu(H-2L)(OH)2-, which is less reactive than Cu(H-2L)- with trien. Values for the stability constants of the hydroxide adduct, KOH (M-1, 25.0°C, μ = 1.0 M), are 41, 10, and 4 for L = GAG, GAibG, and GGA, respectively. A hydroxide adduct is not observed for the Aib3 complex (KOH -1). The Cu(H-2Aib3)- complex behaves differently because the reaction with trien is more sterically hindered. An acid-assisted H2trien2+ path contributes to the observed rate below p[H+] 10, and the rate begins to increase below p[H+] 9.5. However, a proton-transfer step between H3O+ and Cu(H-2Aib3)- (kH = 2.5 × 106 M-1 s-1) can limit the reaction so that it no longer depends on the [trien]T concentration. Above p[H+] 10, the reaction is first order in both [trien]T and [Cu(H-2Aib3)-], and the rate increases to a plateau at p[H+] 12. At higher p[H+] levels the rate is assisted by OH-, in contrast to the inhibition found for the other tripeptides. A third-order rate constant (0.41 M-2 s-1) is found for the path due to [trien][OH-][Cu(H-2Aib3)-].