197299-13-1

Basic information

• Product Name: diethyl 2-(4-benzyloxybenzyl)-2-butylmalonate
• Synonyms: diethyl 2-(4-benzyloxybenzyl)-2-butylmalonate
• CAS NO: 197299-13-1
• Molecular Weight: 412.526
• Mol File: 197299-13-1.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: diethyl 2-(4-benzyloxybenzyl)-2-butylmalonate(CAS DataBase Reference)
• NIST Chemistry Reference: diethyl 2-(4-benzyloxybenzyl)-2-butylmalonate(197299-13-1)
• EPA Substance Registry System: diethyl 2-(4-benzyloxybenzyl)-2-butylmalonate(197299-13-1)

Safety Data

• Hazardous Substances Data: 197299-13-1(Hazardous Substances Data)

Upstream product

• 133-08-4 diethyl butylmalonate 
• 836-42-0 4-benzyloxybenzyl chloride 

Downstream Products

• 197299-14-2 ethyl 2-(4-benzyloxybenzyl)hexanoate 
• 197299-12-0 ethyl 2-(4-hydroxybenzyl)hexanoate 

Relevant articles and documents

Synthesis and biological activity of novel α-substituted β-phenylpropionic acids having pyridin-2-ylphenyl moiety as antihyperglycemic agents

We previously reported the identification of novel oximes having 5-benzyl-2,4-thiazolidinedione with antihyperglycemic activity. We now report the synthesis and biological activity of a novel series of oximes and amides having α-substituted-β-phenylpropionic acids. In this series, we obtained potent PPARα/γ dual agonist (S)-9d, with which activation of PPARα and PPARγ was considerably more potent than that of the reference compounds GW9578 22 and rosiglitazone 3, respectively. This means (S)-9d is of the strongest class of PPARα/γ dual agonists. In the course of this study, we also obtained 8h, which indicated potent plasma glucose lowering effect in spite of weak PPARα/γ agonistic activity.

Phenylalkylcarboxylic acid compounds and compositions for treating hyperglycemia

Phenylalkylcarboxylic acid compounds of the formula: wherein R1 represents an alkyl group and the like, R2 represents an alkylene group, R3 represents a hydrogen atom and the like, X represents a substituted or unsubstituted aryl group and the like, Y represents an oxygen atom and the like, Z represents an alkylene group and the like, and W represents an alkyl group and the like), the pharmacologically acceptable salts thereof or the pharmacologically acceptable esters thereof are useful as therapeutic or preventive agents for hyperglycemia and the like.