197305-97-8

Basic information

• Product Name: 2-Hydrazino-4-(trifluoromethyl)pyrimidine
• Synonyms: BUTTPARK 27\08-68;1-[4-(TRIFLUOROMETHYL)PYRIMIDIN-2-YL]HYDRAZINE;2-HYDRAZINO-4-(TRIFLUOROMETHYL)PYRIMIDINE;N-[4-(TRIFLUOROMETHYL)PYRIMIDIN-2-YL]HYDRAZINE;4-(Trifluoromethyl)pyrimidin-2-ylhydrazine 97%;2-Hydrazino-4-(trifluoromethyl)pyrimidine ,99%;4-(Trifluoromethyl)pyrimidin-2-ylhydrazine;2-hydrazinyl-4-(trifluoroMethyl)pyriMidine
• CAS NO: 197305-97-8
• Molecular Formula: C5H5F3N4
• Molecular Weight: 178.12
• Product Categories: Building Blocks;Heterocyclic Building Blocks;Pyrimidines
• Mol File: 197305-97-8.mol
• Article Data: 0

Chemical Properties

• Melting Point: 99-101 °C(lit.)
• Boiling Point: 281°Cat760mmHg
• Flash Point: 123.7°C
• Appearance: /
• Density: 1.535g/cm³
• Vapor Pressure: 0.00367mmHg at 25°C
• Refractive Index: 1.531
• Storage Temp.: under inert gas (nitrogen or Argon) at 2–8 °C
• Solubility: Soluble in aqueous acid.
• PKA: 5.63±0.40(Predicted)
• CAS DataBase Reference: 2-Hydrazino-4-(trifluoromethyl)pyrimidine(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Hydrazino-4-(trifluoromethyl)pyrimidine(197305-97-8)
• EPA Substance Registry System: 2-Hydrazino-4-(trifluoromethyl)pyrimidine(197305-97-8)

Safety Data

• Hazard Codes: T,Xi
• Statements: 23/24/25-36/37/38
• Safety Statements: 26-36/37/39-45
• RIDADR: UN 2811 6.1/PG 3
• WGK Germany: 3
• HazardClass: IRRITANT, IRRITANT-HARMFUL
• PackingGroup: III
• Hazardous Substances Data: 197305-97-8(Hazardous Substances Data)

Usage

Description

2-Hydrazino-4-(trifluoromethyl)pyrimidine is an organic compound characterized by its white to light yellow solid appearance. It features a pyrimidine ring with a hydrazino group at the 2nd position and a trifluoromethyl group at the 4th position. This unique molecular structure endows it with versatile chemical properties and potential applications in various fields.

Uses

Used in Analytical Chemistry:
2-Hydrazino-4-(triflufluoromethyl)pyrimidine is used as a derivatization reagent for the simultaneous determination of testosterone (T) and dihydrotestosterone (DHT) in murine tissue and serum samples. This application leverages its ability to react with these hormones, allowing for their detection and quantification using liquid chromatography-electrospray ionization-tandem mass spectrometry.
Used in Coordination Chemistry:
In the field of coordination chemistry, 2-Hydrazino-4-(trifluoromethyl)pyrimidine serves as a valuable building block for the synthesis of organohydrazide chelate complexes of rhenium and technetium. These complexes exhibit a metal-nitrogen-nitrogen linkage, which is crucial for their stability and potential applications in catalysis, sensing, or as therapeutic agents.
Used in Organic Synthesis:
2-Hydrazino-4-(trifluoromethyl)pyrimidine is also utilized in the preparation of specific organic compounds, such as 1-(4-methoxyphenyl)ethanone [(4-trifluoromethyl)pyrimidine-2-yl]hydrazone (NAS-75). This synthesis showcases its potential as a key intermediate in the development of new pharmaceuticals or other organic molecules with desired properties.

InChI:InChI=1/C5H5F3N4/c6-5(7,8)3-1-2-10-4(11-3)12-9/h1-2H,9H2,(H,10,11,12)