197388-46-8

Basic information

• Product Name: ethyl 7-(Benzyloxy)chroman-2-carboxylate
• Synonyms: ethyl 7-(Benzyloxy)chroman-2-carboxylate
• CAS NO: 197388-46-8
• Molecular Weight: 312.365
• Mol File: 197388-46-8.mol
• Article Data: 7

Chemical Properties

• CAS DataBase Reference: ethyl 7-(Benzyloxy)chroman-2-carboxylate(CAS DataBase Reference)
• NIST Chemistry Reference: ethyl 7-(Benzyloxy)chroman-2-carboxylate(197388-46-8)
• EPA Substance Registry System: ethyl 7-(Benzyloxy)chroman-2-carboxylate(197388-46-8)

Safety Data

• Hazardous Substances Data: 197388-46-8(Hazardous Substances Data)

Upstream product

• 96566-14-2 (R)-3,4-dihydro-7-hydroxy-2H-1-benzopyran-2-carboxylic acid,ethyl ester 
• 100-39-0 benzyl bromide 
• 584-08-7 potassium carbonate 
• 100-44-7 benzyl chloride 
• 89-84-9 2',4'-dihydroxy-4-acetophenone 
• 23866-72-0 ethyl 7-hydroxy-4-oxo-4H-chromen-2-carboxylate 

Downstream Products

• 1309652-23-0 7-benzyloxy-2-ethoxymethyl-chroman 
• 96565-67-2 rac-5-<3,4-dihydro-7-(phenylmethoxy)-2H-1-benzopyran-2-yl>-2,4-pentadienoic acid ethyl ester 
• 122443-75-8 rac-3,4-dihydro-7-(phenylmethoxy)-2-(2-propenyl)-2H-1-benzopyran-2-carboxylic acid methyl ester 
• 122443-73-6 rac-3,4-dihydro-7-(phenylmethoxy)-2H-1-benzopyran-2-carboxylic acid methyl ester 
• 122443-74-7 rac-3,4-dihydro-2-methyl-7-(phenylmethoxy)-2H-1-benzopyran-2-carboxylic acid methyl ester 
• 180716-26-1 [3-(benzoxazol-6-yloxy)-propyl]-(7-benzyloxy-chroman-2-ylmethyl)amine 
• 180716-29-4 [3-(Benzooxazol-5-yloxy)-propyl]-(7-benzyloxy-chroman-2-ylmethyl)-amine 
• 180716-31-8 4-{3-[(7-Benzyloxy-chroman-2-ylmethyl)-amino]-propoxy}-pyrimidin-2-ylamine 
• 180716-30-7 [3-(3-Methyl-benzo[d]isoxazol-6-yloxy)-propyl]-(7-benzyloxy-chroman-2-ylmethyl)-amine 
• 199738-77-7 (7-Benzyloxy-chroman-2-ylmethyl)-naphthalen-1-ylmethyl-amine 

Relevant articles and documents

Design and optimization of 2,3-dihydrobenzo[b][1,4]dioxine propanoic acids as novel GPR40 agonists with improved pharmacokinetic and safety profiles

GPR40 has become a new potential therapeutic target for the treatment of diabetes due to its role in mediating the enhancement of glucose-stimulated insulin secretion in pancreatic β cells with a low risk of hypoglycemia. As an effort to extend the chemical space and identify structurally distinct GPR40 agonists with improved liver safety, a novel series of fused-ring phenyl propanoic acid analogues were designed. Comprehensive structure-activity relationship studies around novel scaffolds were conducted and led to several analogues exhibited potent GPR40 agonistic activities and high selectivity against other fatty acid receptors. Further evaluation of pharmacokinetic (PK) profiles and in vivo efficacy identified compound 40a with excellent PK properties and significant glucose-lowering efficacy during an oral glucose tolerance test. In addition, compound 40a displayed lower hepatobiliary transporter inhibition and favorable druggability. All results indicate that compound 40a is a promising candidate for further development.

(2R)-2-ethylchromane-2-carboxylic acids: Discovery of novel PPARα/γ dual agonists as antihyperglycemic and hypolipidemic agents

A series of chromane-2-carboxylic acid derivatives was synthesized and evaluated for PPAR agonist activities. A structure-activity relationship was developed toward PPARα/γ dual agonism. As a result, (2R)-7-{3-[2-chloro-4-(4-fluorophenoxy)phenoxy]propoxy}

Benzopyrancarboxylic acid derivatives for the treatment of diabetes and lipid disorders

A class of benzopyrancarboxylic acid derivatives comprises compounds that are potent agonists of PPAR alpha and/or gamma, and are therefore useful in the treatment, control or prevention of non-insulin dependent diabetes mellitus (NIDDM), hyperglycemia, dyslipidemia, hyperlipidemia, hypercholesterolemia, hypertriglyceridemia, atherosclerosis, obesity, vascular restenosis, inflammation, and other PPAR alpha and/or gamma mediated diseases, disorders and conditions.