19739-40-3

Basic information

• Product Name: 3(2H)-benzoxazoleacetic acid, 6-chloro-2-oxo-
• Synonyms: (6-chloro-2-oxo-1,3-benzoxazol-3(2H)-yl)acetic acid;3(2H)-benzoxazoleacetic acid, 6-chloro-2-oxo-;(6-Chloro-2-oxo-benzooxazol-3-yl)-acetic acid;2-(6-chloro-2-keto-1,3-benzoxazol-3-yl)acetic acid;2-(6-chloro-2-oxo-1,3-benzoxazol-3-yl)acetic acid;2-(6-chloro-2-oxo-1,3-benzoxazol-3-yl)ethanoic acid;BAS 10307594;EU-0066565
• CAS NO: 19739-40-3
• Molecular Formula: C₉H₆ClNO₄
• Molecular Weight: 227.60124
• Mol File: 19739-40-3.mol
• Article Data: 2

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 3(2H)-benzoxazoleacetic acid, 6-chloro-2-oxo-(CAS DataBase Reference)
• NIST Chemistry Reference: 3(2H)-benzoxazoleacetic acid, 6-chloro-2-oxo-(19739-40-3)
• EPA Substance Registry System: 3(2H)-benzoxazoleacetic acid, 6-chloro-2-oxo-(19739-40-3)

Safety Data

• HazardClass: IRRITANT
• Hazardous Substances Data: 19739-40-3(Hazardous Substances Data)

Upstream product

• 28443-50-7 2-amino-5-chlorophenol 
• 19932-84-4 6-chlorobenzo[d]oxazol-2(3H)-one 
• 105-39-5 chloroacetic acid ethyl ester 
• 59-49-4 2-Benzoxazolinone 
• 13610-49-6 2-[2-oxo-benzo[d]oxazole-3(2H)-yl]acetic acid 
• 79-11-8 chloroacetic acid 

Relevant articles and documents

Development of benzo[d]oxazol-2(3H)-ones derivatives as novel inhibitors of Mycobacterium tuberculosis InhA

A series of twenty seven substituted 2-(2-oxobenzo[d]oxazol-3(2H)-yl)acetamide derivatives were designed based on our earlier reported Mycobacterium tuberculosis (MTB) enoyl-acyl carrier protein reductase (InhA) lead. Compounds were evaluated for MTB InhA inhibition study, in vitro activity against drug-sensitive and -resistant MTB strains, and cytotoxicity against RAW 264.7 cell line. Among the compounds tested, 2-(6-nitro-2-oxobenzo[d]oxazol-3(2H)-yl)-N-(5-nitrothiazol-2-yl)acetamide (30) was found to be the most promising compound with IC50 of 5.12 ± 0.44 μM against MTB InhA, inhibited drug sensitive MTB with MIC 17.11 μM and was non-cytotoxic at 100 μM. The interaction with protein and enhancement of protein stability in complex with compound 30 was further confirmed biophysically by differential scanning fluorimetry.