19740-01-3

Basic information

• Product Name: 3-cyclohexyl-1-(thiophen-2-yl)propan-1-one
• Synonyms: 3-cyclohexyl-1-(thiophen-2-yl)propan-1-one
• CAS NO: 19740-01-3
• Molecular Weight: 222.351
• Mol File: 19740-01-3.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 3-cyclohexyl-1-(thiophen-2-yl)propan-1-one(CAS DataBase Reference)
• NIST Chemistry Reference: 3-cyclohexyl-1-(thiophen-2-yl)propan-1-one(19740-01-3)
• EPA Substance Registry System: 3-cyclohexyl-1-(thiophen-2-yl)propan-1-one(19740-01-3)

Safety Data

• Hazardous Substances Data: 19740-01-3(Hazardous Substances Data)

Upstream product

• 188290-36-0 thiophene 
• 39098-75-4 3-cyclohexylpropionyl chloride 
• 98-89-5 Cyclohexanecarboxylic acid 
• 88-15-3 2-Acetylthiophene 
• 888505-23-5 1-(thiophen-2-yl)cyclopropan-1-ol 
• 126812-30-4 1,3-dioxoisoindolin-2-yl cyclohexanecarboxylate 
• 87801-93-2 trimethyl(1-(thiophen-2-yl)cyclopropoxy)silane 
• 62889-07-0 trimethyl((1-(thiophen-2-yl)vinyl)oxy)silane 

Downstream Products

• 19740-02-4 2-(3-cyclohexyl-propyl)-thiophene 
• 854007-38-8 5-(3-cyclohexylpropyl)-2-formylthiophene 

Relevant articles and documents

Ni-Catalyzed β-Alkylation of Cyclopropanol-Derived Homoenolates

Metal homoenolates are valuable synthetic intermediates which provide access to β-functionalized ketones. In this report, we disclose a Ni-catalyzed β-alkylation reaction of cyclopropanol-derived homoenolates using redox-active N-hydroxyphthalimide (NHPI) esters as the alkylating reagents. The reaction is compatible with 1°, 2°, and 3° NHPI esters. Mechanistic studies imply radical activation of the NHPI ester and 2e β-carbon elimination occurring on the cyclopropanol.