197653-87-5

Basic information

• Product Name: Methanone, (2-chloro-5-nitrophenyl)(4-fluorophenyl)-
• CAS NO: 197653-87-5
• Molecular Formula: C13H7ClFNO3
• Molecular Weight: 279.655
• Mol File: 197653-87-5.mol
• Article Data: 4

Chemical Properties

• CAS DataBase Reference: Methanone, (2-chloro-5-nitrophenyl)(4-fluorophenyl)-(CAS DataBase Reference)
• NIST Chemistry Reference: Methanone, (2-chloro-5-nitrophenyl)(4-fluorophenyl)-(197653-87-5)
• EPA Substance Registry System: Methanone, (2-chloro-5-nitrophenyl)(4-fluorophenyl)-(197653-87-5)

Safety Data

• Hazardous Substances Data: 197653-87-5(Hazardous Substances Data)

Upstream product

• 462-06-6 fluorobenzene 
• 25784-91-2 2-chloro-5-nitrobenzoylchloride 
• 118-91-2 ortho-chlorobenzoic acid 
• 2516-96-3 2-chloro-5-nitrobenzoic acid 

Downstream Products

• 86187-98-6 [5-Amino-2-(4-methyl-piperidin-1-yl)-phenyl]-(4-fluoro-phenyl)-methanone 
• 197654-16-3 [5-Amino-2-(4-methyl-piperazin-1-yl)-phenyl]-(4-fluoro-phenyl)-methanone 
• 197654-05-0 (4-Fluoro-phenyl)-[2-(4-methyl-piperazin-1-yl)-5-nitro-phenyl]-methanone 
• 132439-22-6 (4-Fluoro-phenyl)-[2-(4-methyl-piperidin-1-yl)-5-nitro-phenyl]-methanone 

Relevant articles and documents

Synthesis method for (2-chloro-5-iodophenyl)(4-fluorophenyl)ketone

The invention discloses a synthesis method for (2-chloro-5-iodophenyl)(4-fluorophenyl)ketone. According to the method, with cheap o-chlorobenzoic acid as a starting material, (2-chloro-5-iodophenyl)(4-fluorophenyl)ketone is obtained by nitration, Friedel-Crafts acylation and reduction and finally by Sandmeyer reaction for iodination. The materials used by the method are cheap and easy to obtain, and the method adopting Sandmeyer reaction for iodination can increase the iodine utilization rate, and has the characteristics of simplicity in operation, high yield, high purity and suitability for industrialized production. (The chemical formula is shown in the specification).

Synthesis and antitumor activity of novel benzophenone derivatives

Novel benzophenone derivatives were synthesized and screened for cytotoxic and antitumor activity. Friedel-Crafts condensation was employed to construct the benzophenone skeleton. Among the compounds synthesized, morpholino and thiomorpholino benzophenones 3a-d exhibited potent cytotoxic activity against P388 murine leukemia and PC-6 human lung carcinoma cells in vitro, and compounds 3a, 3c, and 3j, when administered intraperitoneally, showed significant antitumor activity against the malignant ascites caused by intraperitoneal inoculation of P388 cells in mice.