197777-90-5

Basic information

• Product Name: Benzene, 4-ethenyl-2-fluoro-1-nitro-
• CAS NO: 197777-90-5
• Molecular Formula: C8H6FNO2
• Molecular Weight: 167.14
• Mol File: 197777-90-5.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: Benzene, 4-ethenyl-2-fluoro-1-nitro-(CAS DataBase Reference)
• NIST Chemistry Reference: Benzene, 4-ethenyl-2-fluoro-1-nitro-(197777-90-5)
• EPA Substance Registry System: Benzene, 4-ethenyl-2-fluoro-1-nitro-(197777-90-5)

Safety Data

• Hazardous Substances Data: 197777-90-5(Hazardous Substances Data)

Upstream product

• 131858-37-2 4-(bromomethyl)-2-fluoro-1-nitrobenzene 
• 321-23-3 4-bromo-2-fluoronitrobenzene 
• 7486-35-3 tri-n-butyl(vinyl)tin 
• 446-34-4 2-fluoro-4-methyl-1-nitrobenzene 
• 50-00-0 formaldehyd 

Downstream Products

• 388612-82-6 4-(N-benzyl-pyrrolid-3-yl)-2-fluoro-nitrobenzene 
• 197777-96-1 ((1R,2R)-2-(tert-Butyl-dimethyl-silanyloxy)-2-(3-chloro-4-hydroxy-phenyl)-1-{(S)-2-cyano-1-[(R)-1-(3-fluoro-4-nitro-phenyl)-2-methoxy-ethylcarbamoyl]-ethylcarbamoyl}-ethyl)-carbamic acid tert-butyl ester 
• 197777-95-0 {(S)-2-Cyano-1-[(R)-1-(3-fluoro-4-nitro-phenyl)-2-methoxy-ethylcarbamoyl]-ethyl}-carbamic acid tert-butyl ester 
• 197777-92-7 2-[(R)-2-(tert-Butyl-dimethyl-silanyloxy)-1-(3-fluoro-4-nitro-phenyl)-ethyl]-isoindole-1,3-dione 
• 197777-93-8 2-[(R)-1-(3-Fluoro-4-nitro-phenyl)-2-methoxy-ethyl]-isoindole-1,3-dione 
• 197777-99-4 2-[(R)-1-(3-Fluoro-4-nitro-phenyl)-2-hydroxy-ethyl]-isoindole-1,3-dione 
• 197778-00-0 (S)-2-Amino-3-cyano-N-[(R)-1-(3-fluoro-4-nitro-phenyl)-2-methoxy-ethyl]-propionamide 
• 197777-94-9 (R)-1-(3-Fluoro-4-nitro-phenyl)-2-methoxy-ethylamine 
• 331731-43-2 C₅₄H₆₆FN₅O₁₆Si 
• 331731-45-4 [1-({{3-[5-(2-benzyloxy-1-tert-butoxycarbonylamino-ethyl)-2-methoxy-phenoxy]-5-methoxy-phenyl}-[1-(3,5-dihydroxy-4-methoxy-phenyl)-2-hydroxy-ethylcarbamoyl]-methyl}-carbamoyl)-2-(4-fluoro-3-nitro-phenyl)-ethyl]-carbamic acid tert-butyl ester 

Relevant articles and documents

HETEROCYCLIC COMPOUNDS SUITABLE FOR TREATING DISORDERS THAT RESPOND TO MODULATION OF THE DOPAMINE D3 RECEPTOR

The invention relates to compounds of the formula (I) wherein n is 0, 1 or 2; G is CH2 or CHR3; R1 is H, C,-C6-alkyl, C,-C6-alkyl substituted by C3-C6-cycloalkyl, Cl-C6-hydroxyalkyl, fluorinated C,-C6-alkyl, C3-C6-cycloalkyl, fluorinated C3-C6-cycloalkyl, C3-C6- alkenyl, fluorinated C3-C6-alkenyl, formyl, acetyl or propionyl; R2, R3 and R4 are, independently of each other, H, methyl, fluoromethyl, difluoromethyl, or trifluoromethyl; A is phenylene, pyridylene, pyrimidylene, pyrazinylene, pyridazinylene or thiophenylene, which can be substituted by one ore more substituents selected from halogen, methyl, methoxy and CF3; E is NR5 or CH2, wherein R5 is H or C1 -C3-alkyl; Ar is a cyclic radical selected from the group consisting of phenyl, a 5- or 6- -membered heteroaromatic radical comprising as ring members 1, 2 or 3 heteroatoms selected from N, O and S and a phenyl ring fused to a saturated or unsaturated 5- or 6-membered carbocyclic or heterocyclic ring, where the heterocyclic ring comprises as ring members 1, 2 or 3 heteroatoms selected from N, O and S and/or 1, 2 or 3 heteroatom-containing groups each independently selected from NR8, where R8 is H, C1-C4-alkyl, fluorinated C1-C4-alkyl, C1-C4-alkylcarbonyl or fluorinated C1-C4-alkylcarbonyl, and where the cyclic radical Ar may carry 1, 2 or 3 substituents Ra, wherein the variable Ra has the meanings given in the claims and in the description; and physiologically tolerated acid addition salts thereof. The invention also relates to the use of a compound of the formula I or a pharmaceutically acceptable salt thereof for preparing a pharmaceutical composition for the treatment of a medical disorder susceptible to treatment with a dopamine D3 receptor ligand.