1978-61-6 Usage
Description
4-(4-FLUOROPHENYL)-1,2,3,6-TETRAHYDROPYRIDINE HYDROCHLORIDE is a chemical compound that serves as a reagent in the synthesis of various pharmaceutical compounds. It is characterized by its light yellow to beige powder appearance.
Uses
Used in Pharmaceutical Industry:
4-(4-FLUOROPHENYL)-1,2,3,6-TETRAHYDROPYRIDINE HYDROCHLORIDE is used as a reagent for the preparation of 4-phenyl-tetrahydrophenyl substituted oxazolidinone derivatives. These derivatives possess potent central nervous depressant, analgesic, and anti-inflammatory activities, as well as acting as α1A adrenergic receptor antagonists. This makes them valuable in the development of medications for various medical conditions, including pain management, inflammation, and certain neurological disorders.
Check Digit Verification of cas no
The CAS Registry Mumber 1978-61-6 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 1,9,7 and 8 respectively; the second part has 2 digits, 6 and 1 respectively.
Calculate Digit Verification of CAS Registry Number 1978-61:
(6*1)+(5*9)+(4*7)+(3*8)+(2*6)+(1*1)=116
116 % 10 = 6
So 1978-61-6 is a valid CAS Registry Number.
InChI:InChI=1/C11H12FN/c12-11-3-1-9(2-4-11)10-5-7-13-8-6-10/h1-5,13H,6-8H2/p+1
1978-61-6Relevant articles and documents
Synthesis and dopaminergic activity of some 3-(1,2,3,6-tetrahydro-1- pyridylalkyl)indoles. A novel conformational model to explain structure- activity relationships
Bottcher,Barnickel,Hausberg,Haase,Seyfried,Eiermann
, p. 4020 - 4026 (2007/10/02)
The synthesis and dopaminergic properties of a novel type of dopamine agonist is described. The number and kind of essential structural elements differ significantly from that of the rigid apomorphine-type dopamine agonists. Using standard molecular modeling techniques, a conformational model is developed proposing a U-shaped conformation which might be energetically preferred through aromatic π-π-interactions between both of the electron rich aromatic structural elements of this class of compounds. Superimposition of conformations of the lead compound 28 with apomorphine yields a novel model explaining the atypical structure-activity relationships found in this class of indolealkylamines.