197847-57-7

Basic information

• Product Name: Benzenesulfonamide, N-[2-(hydroxymethyl)phenyl]-
• CAS NO: 197847-57-7
• Molecular Formula: C13H13NO3S
• Molecular Weight: 263.317
• Mol File: 197847-57-7.mol
• Article Data: 8

Chemical Properties

• CAS DataBase Reference: Benzenesulfonamide, N-[2-(hydroxymethyl)phenyl]-(CAS DataBase Reference)
• NIST Chemistry Reference: Benzenesulfonamide, N-[2-(hydroxymethyl)phenyl]-(197847-57-7)
• EPA Substance Registry System: Benzenesulfonamide, N-[2-(hydroxymethyl)phenyl]-(197847-57-7)

Safety Data

• Hazardous Substances Data: 197847-57-7(Hazardous Substances Data)

Upstream product

• 5344-90-1 2-Aminobenzyl alcohol 
• 98-59-9 p-toluenesulfonyl chloride 
• 98-09-9 benzenesulfonyl chloride 
• 34837-67-7 2-(phenylsulfonamido)benzoic acid 

Downstream Products

• 1613505-54-6 C₂₃H₁₇NO₃S 
• 10447-54-8 1-benzenesulfonyl-2-methyl-2,3-dihydro-1H-quinolin-4-one 
• 6590-65-4 N-(2-Formyl-phenyl)-4-methyl-benzenesulfonamide 
• 1015760-83-4 (E)-N-(2-(3-oxo-3-phenylprop-1-en-1-yl)phenyl)benzenesulfonamide 

Relevant articles and documents

Synthesis of novel spiro-tetrahydroquinoline derivatives and evaluation of their pharmacological effects on wound healing

A highly diastereoselective method for the synthesis of novel spiro-tetrahydroquinoline derivatives is reported here, using a one-pot reaction method. All compounds were characterized by1 H-nuclear magnetic resonance (NMR) and mass spectroscopy

Ynamide Smiles Rearrangement Triggered by Visible-Light-Mediated Regioselective Ketyl-Ynamide Coupling: Rapid Access to Functionalized Indoles and Isoquinolines

In the past decades, significant advances have been made on radical Smiles rearrangement. However, the eventually formed radical intermediates in these reactions are limited to the amidyl radical, except for the few examples initiated by a N-centered radical. Here, a novel and practical radical Smiles rearrangement triggered by photoredox-catalyzed regioselective ketyl-ynamide coupling is reported, which represents the first radical Smiles rearrangement of ynamides. This method enables facile access to a variety of valuable 2-benzhydrylindoles with broad substrate scope in generally good yields under mild reaction conditions. In addition, this chemistry can also be extended to the divergent synthesis of versatile 3-benzhydrylisoquinolines through a similar ketyl-ynamide coupling and radical Smiles rearrangement, followed by dehydrogenative oxidation. Moreover, such an ynamide Smiles rearrangement initiated by intermolecular photoredox catalysis via addition of external radical sources is also achieved. By control experiments, the reaction was shown to proceed via key ketyl radical and α-imino carbon radical intermediates.

Amphoteric 2-(sulfonylamino)benzaldehydes, secondary amines and isocyanides in the multicomponent synthesis of elusive N-alkyl-2,3-diaminoindoles

A novel interrupted Ugi reaction between ortho-sulfonylaminated aryl aldehydes, secondary amines, and isocyanides affords in good to high yields N-alkyl-2,3-diaminoindoles, providing access to a so far unexplored area of the indole chemical space. With only one single chemical operation, this novel reaction affords a broad gamma of substituted 2,3-diaminoindoles with five points of diversity. The success of this novel multicomponent transformation lies in presence of the amphoteric sulfonylamino group, which sequentially acts as a Br?nsted acids and as a nucleophile the lack of need for additional catalysts and the high atom economy, with the loss of only one molecule of water, renders this approach a very effective one.