197852-02-1

Basic information

• Product Name: ethyl (S)-3-hydroxy-3-phenylbutanoate
• Synonyms: ethyl (S)-3-hydroxy-3-phenylbutanoate
• CAS NO: 197852-02-1
• Molecular Weight: 165.192
• Mol File: 197852-02-1.mol
• Article Data: 5

Chemical Properties

• CAS DataBase Reference: ethyl (S)-3-hydroxy-3-phenylbutanoate(CAS DataBase Reference)
• NIST Chemistry Reference: ethyl (S)-3-hydroxy-3-phenylbutanoate(197852-02-1)
• EPA Substance Registry System: ethyl (S)-3-hydroxy-3-phenylbutanoate(197852-02-1)

Safety Data

• Hazardous Substances Data: 197852-02-1(Hazardous Substances Data)

Upstream product

• 614-16-4 Benzoylacetonitrile 
• 1191104-09-2 3-phenyl-3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)propanamide 
• 3446-58-0 3-oxo-3-phenylpropanamide 
• 132203-26-0 (S)-3-hydroxy-3-phenylpropanenitrile 

Downstream Products

• 36567-72-3 (S)-3-hydroxy-3-phenylpropanoic acid 
• 96854-34-1 (S)-3-phenyl-1,3-propanediol 
• 33401-74-0 ethyl (3R)-3-hydroxy-3-phenylpropionate 

Relevant articles and documents

Strengthening the Combination between Enzymes and Metals in Aqueous Medium: Concurrent Ruthenium-Catalyzed Nitrile Hydration - Asymmetric Ketone Bioreduction

A dual ruthenium/ketoreductase catalytic system has been developed for the conversion of β-ketonitriles into optically active β-hydroxyamides through an unprecedented hydration/bioreduction cascade process in aqueous medium working in concurrent mode. The ketoreductase-mediated ketone reduction took place with exquisite stereoselectivity and it was simultaneous to the nitrile hydration promoted by the ruthenium catalyst. The overall transformation occurred: (i) employing commercially and readily available catalytic systems (ii) under mild reaction conditions, (iii) with high degree of conversion and excellent stereoselectivity, and (iv) without the need to isolate intermediates and with high final product yields. This genuine process demonstrates the benefits of combining metal and enzymatic catalysis to tackle the limitations arising from each field.

Chiral iridium catalysts bearing spiro pyridine-aminophosphine ligands enable highly efficient asymmetric hydrogenation of β-aryl β-ketoesters

Tons of TONs: Chiral iridium catalysts bearing ligand 1 are highly efficient for the asymmetric hydrogenation of β-substituted β-ketoesters. The product β-hydroxyesters are delivered in high yield with excellent enantioselectivities and high turnover numbers (TONs). cod= 1,5-cyclooctadiene.

Enantioselective reduction of β-keto amides by the fungus Mortierella isabellina

Incubations of the fungus Mortierella isabellina NRRL 1757 with 3-oxo-3-phenylpropanamide, 3-oxobutanamide and with some of their N-alkyl derivatives afford the corresponding (S)-3-hydroxyamides usually in high chemical yields and enantiomeric excesses.