19786-48-2 Usage
Description
(4-Nitrophenoxy)acetic acid methyl ester, also known as Methyl 4-Nitrophenoxyacetate, is an organic compound that serves as a crucial intermediate in the synthesis of various pharmaceutical compounds. It is characterized by its ester functional group and a nitro group attached to the phenoxy ring, which contributes to its reactivity and potential applications in the chemical and pharmaceutical industries.
Uses
Used in Pharmaceutical Synthesis:
(4-Nitrophenoxy)acetic acid methyl ester is used as an intermediate in the synthesis of isotopically labeled analogues of pharmaceutical compounds. It plays a vital role in the production of 2-(4-(Methylsulfonamido)phenoxy)acetic Acid-13C (M332217), which is an isotopically labeled analogue of 2-(4-(Methylsulfonamido)phenoxy)acetic Acid (M332215). This metabolite is derived from the antiarrhythmic drug Dofetilide (D525700), a potassium channel blocker.
Used in the Synthesis of Dofetilide Metabolites:
(4-Nitrophenoxy)acetic acid methyl ester is used as a key component in the synthesis of metabolites of Dofetilide, an antiarrhythmic drug. This application is significant in the development and understanding of the drug's pharmacokinetics, pharmacodynamics, and potential side effects, as well as in the design of new drugs with improved efficacy and safety profiles.
Used in the Chemical Industry:
In the chemical industry, (4-Nitrophenoxy)acetic acid methyl ester may be utilized as a building block for the synthesis of various organic compounds, including those with potential applications in materials science, agrochemicals, and other specialized fields. Its reactivity and functional groups make it a versatile starting material for the development of new molecules with specific properties and applications.
Check Digit Verification of cas no
The CAS Registry Mumber 19786-48-2 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 1,9,7,8 and 6 respectively; the second part has 2 digits, 4 and 8 respectively.
Calculate Digit Verification of CAS Registry Number 19786-48:
(7*1)+(6*9)+(5*7)+(4*8)+(3*6)+(2*4)+(1*8)=162
162 % 10 = 2
So 19786-48-2 is a valid CAS Registry Number.
19786-48-2Relevant articles and documents
Rapid and high-yield synthesis of aryloxyacetates under microwave irradiation and phase-transfer catalysis conditions
Wei, Tai-Bao,Liu, Hong,Li, Man-Lin,Zhang, You-Ming
, p. 1759 - 1764 (2005)
A series of methyl aryloxyacetates (3a-3f) have been synthesized by the reaction of substituted phenol with methyl chloroacetate under the conditions of microwave irradiation and phase-transfer catalysis. By the optimization of the reaction conditions, we developed a good method for the preparation of methyl aryloxyacetates, which have the advantages of high yields, short reaction times, ease of workup, and simple operation. Copyright Taylor & Francis, Inc.
Selective Janus Kinase 2 (JAK2) Pseudokinase Ligands with a Diaminotriazole Core
Liosi, Maria-Elena,Krimmer, Stefan G.,Newton, Ana S.,Dawson, Thomas K.,Puleo, David E.,Cutrona, Kara J.,Suzuki, Yoshihisa,Schlessinger, Joseph,Jorgensen, William L.
, p. 5324 - 5340 (2020/06/10)
Janus kinases (JAKs) are non-receptor tyrosine kinases that are essential components of the JAK-STAT signaling pathway. Associated aberrant signaling is responsible for many forms of cancer and disorders of the immune system. The present focus is on the d
New: N -phenyl-4,5-dibromopyrrolamides as DNA gyrase B inhibitors
Zidar, Nace,Macut, Helena,Toma?i?, Tihomir,Peterlin Ma?i?, Lucija,Ila?, Janez,Zega, Anamarija,Tammela, P?ivi,Kikelj, Danijel
supporting information, p. 1007 - 1017 (2019/06/27)
Due to the rapid development of antimicrobial resistance, the discovery of new antibacterials is essential in the fight against potentially lethal infections. The DNA gyrase B (GyrB) subunit of bacterial DNA gyrase is an excellent target for the design of
