197896-26-7Relevant articles and documents
Synthesis of anti-tumour phosphatidylinositol analogues from glucose by the use of ring-closing olefin metathesis
Andresen, Thomas L.,Skytte, Dorthe M.,Madsen, Robert
, p. 2951 - 2957 (2007/10/03)
A divergent strategy is described for synthesis of the novel phosphatidylinositols 1-3. The synthetic approach commences from benzyl-protected methyl 6-iodo-6-deoxy-α-D-glucopyranoside, which undergoes zinc-mediated reductive fragmentation followed by vin
Novel PI analogues selectively block activation of the pro-survival serine/threonine kinase Akt
Kozikowski, Alan P.,Sun, Haiying,Brognard, John,Dennis, Phillip A.
, p. 1144 - 1145 (2007/10/03)
The synthesis from l-quebrachitol of a series of 3-deoxygenated ether lipid-type phosphatidylinositol (PI) analogues is reported, that selectively block activation of Akt and downstream substrates without affecting activation of the upstream kinase, PDK-1