198065-30-4

Basic information

• Product Name: N-[(tritylmercapto)acetyl]glycylglycylglycine
• Synonyms: N-[(tritylmercapto)acetyl]glycylglycylglycine
• CAS NO: 198065-30-4
• Molecular Weight: 505.594
• Mol File: 198065-30-4.mol
• Article Data: 4

Chemical Properties

• CAS DataBase Reference: N-[(tritylmercapto)acetyl]glycylglycylglycine(CAS DataBase Reference)
• NIST Chemistry Reference: N-[(tritylmercapto)acetyl]glycylglycylglycine(198065-30-4)
• EPA Substance Registry System: N-[(tritylmercapto)acetyl]glycylglycylglycine(198065-30-4)

Safety Data

• Hazardous Substances Data: 198065-30-4(Hazardous Substances Data)

Upstream product

• 76-83-5 trityl chloride 
• 34914-36-8 2-(triphenylmethylthio)ethanoic acid 
• 556-33-2 glycine-glycine-glycine 
• 91425-31-9 2-(triphenylmethylthio)ethanoic acid-N-hydroxysuccinimido ester 

Relevant articles and documents

Synthesis and biological evaluation of technetium-99m-labeled deoxyglucose derivatives as imaging agents for tumor

Three deoxyglucose (DG) derivatives, S-DG, MAG3-DG and MAMA-BA-DG, were synthesized and labeled successfully with high labeling yields and high radio-chemical purities. Biodistribution in tumor-bearing mice demonstrated that these three new su

Novel [99mTcN]2+ labeled EGFR inhibitors as potential radiotracers for single photon emission computed tomography (SPECT) tumor imaging

The epidermal growth factor receptor (EGFR) is overexpressed in many cancers, including breast, ovarian, endometrial and non-small cell lung cancer. An EGFR-specific imaging agent could facilitate clinical evaluation of primary tumors or metastases. To achieve this goal, 4-(2-aminoethylamino)-6,7- dimethoxyquinazoline (ADMQ) was synthesized based on a 4-aminoquinazoline core and then conjugated with N-mercapto-acetylglycine (MAG) and N- mercaptoacetyltriglycine (MAG3), respectively, to give compounds 1 and 2. The final complexes [99mTcN]-1 and [99mTcN]-2 were successfully obtained with radiochemical purities of >99% and >98% as measured by radio-HPLC. No decomposition of the two complexes at room temperature was observed over a period of 2 h. Their partition coefficients indicated they were hydrophilic and the electrophoresis results showed they were negatively charged. Biodistribution in tumor-bearing mice demonstrated that the two new complexes showed tumor accumulation, high tumor-tomuscle (T/M) ratios and fast clearance from blood and muscle. Between the two compounds, the 99mTcN-MAG3-ADMQ ([99mTcN]-2) showed the better characteristics, with the tumor/muscle and tumor/blood ratios reached 2.11 and 1.90 at 60 min post-injection, 4.20 and 1.10 at 120 min post-injection, suggesting it could be a promising radiotracer for SPECT tumor imaging.