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1984-15-2

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1984-15-2 Usage

Description

Methylenediphosphonic acid (MDP) is a phosphonic analog of ATP, characterized as a colorless solid. It is a 1,1-bis(phosphonic acid) consisting of methane substituted by two phosphonic acid groups. MDP possesses unique chemical properties that make it suitable for various applications across different industries.

Uses

Used in Medical Imaging:
Methylenediphosphonic acid is used as a radioactive imaging agent for skeletal imaging. It plays a crucial role in diagnosing and monitoring bone-related conditions, such as fractures, infections, and tumors.
Used in Cell Culture Studies:
MDP is utilized as a chelating agent to manipulate calcium levels in cell culture. This application has been particularly useful in a study of caffeine storage in bovine chromaffin cells, where MDP helped researchers understand the underlying mechanisms.
Used in Chemical Synthesis:
Methylenediphosphonic acid serves as a precursor in the synthesis of various compounds, such as mesoporous aluminum organophosphonate. This synthesis process involves the use of alkyltrimethylammonium as a surfactant, which aids in creating materials with specific properties for various applications.
Used in Nuclear Industry:
MDP is used as a precursor in the synthesis of tetraester of methylenediphosphonic acids, which are employed as metal ion extractants for actinides in all oxidation states. This application is vital in the nuclear industry for the safe and efficient management of radioactive materials.

Check Digit Verification of cas no

The CAS Registry Mumber 1984-15-2 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 1,9,8 and 4 respectively; the second part has 2 digits, 1 and 5 respectively.
Calculate Digit Verification of CAS Registry Number 1984-15:
(6*1)+(5*9)+(4*8)+(3*4)+(2*1)+(1*5)=102
102 % 10 = 2
So 1984-15-2 is a valid CAS Registry Number.
InChI:InChI=1/CH6O6P2/c2-8(3,4)1-9(5,6)7/h1H2,(H2,2,3,4)(H2,5,6,7)

1984-15-2 Well-known Company Product Price

  • Brand
  • (Code)Product description
  • CAS number
  • Packaging
  • Price
  • Detail
  • TCI America

  • (M0843)  Methylenediphosphonic Acid  >97.0%(T)

  • 1984-15-2

  • 1g

  • 510.00CNY

  • Detail
  • TCI America

  • (M0843)  Methylenediphosphonic Acid  >97.0%(T)

  • 1984-15-2

  • 5g

  • 1,790.00CNY

  • Detail
  • Alfa Aesar

  • (30279)  Methylenediphosphonic acid, 97%   

  • 1984-15-2

  • 1g

  • 668.0CNY

  • Detail
  • Alfa Aesar

  • (30279)  Methylenediphosphonic acid, 97%   

  • 1984-15-2

  • 5g

  • 1852.0CNY

  • Detail
  • Alfa Aesar

  • (30279)  Methylenediphosphonic acid, 97%   

  • 1984-15-2

  • 25g

  • 7987.0CNY

  • Detail
  • Alfa Aesar

  • (A14803)  Methylenediphosphonic acid, 99+%   

  • 1984-15-2

  • 1g

  • 810.0CNY

  • Detail
  • Alfa Aesar

  • (A14803)  Methylenediphosphonic acid, 99+%   

  • 1984-15-2

  • 5g

  • 1870.0CNY

  • Detail
  • Alfa Aesar

  • (A14803)  Methylenediphosphonic acid, 99+%   

  • 1984-15-2

  • 25g

  • 8077.0CNY

  • Detail
  • Sigma-Aldrich

  • (M0240000)  Medronicacid  European Pharmacopoeia (EP) Reference Standard

  • 1984-15-2

  • M0240000

  • 1,880.19CNY

  • Detail
  • Sigma

  • (64255)  Methylenediphosphonicacid  for molecular studies & mass spectrometry

  • 1984-15-2

  • 64255-1G-F

  • 1,855.62CNY

  • Detail
  • Sigma

  • (64255)  Methylenediphosphonicacid  for molecular studies & mass spectrometry

  • 1984-15-2

  • 64255-5G-F

  • 7,411.95CNY

  • Detail
  • Sigma

  • (64255)  Methylenediphosphonicacid  for molecular studies & mass spectrometry

  • 1984-15-2

  • 64255-25G-F

  • 29,624.40CNY

  • Detail

1984-15-2SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 11, 2017

Revision Date: Aug 11, 2017

1.Identification

1.1 GHS Product identifier

Product name medronic acid

1.2 Other means of identification

Product number -
Other names Medronic Acid

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:1984-15-2 SDS

1984-15-2Relevant articles and documents

Bisphosphonates derived from fatty acids are potent inhibitors of Trypanosoma cruzi farnesyl pyrophosphate synthase

Szajnman, Sergio H.,Montalvetti, Andrea,Wang, Youhong,Docampo, Roberto,Rodriguez, Juan B.

, p. 3231 - 3235 (2003)

Studies on the mode of action of a series of bisphosphonates derived from fatty acids, which had previously proved to be potent inhibitors against Trypanosoma cruzi proliferation in in vitro assays, have been performed. Some of these drugs proved to be potent inhibitors against the intracellular form of the parasite, exhibiting IC50 values at the low micromolar level. As bisphosphonates are FDA clinically approved for treatment of bone resorption disorders, their potential innocuousness makes them good candidates to control tropical diseases.

Challenging synthesis of bisphosphonate derivatives with reduced steric hindrance

Chiminazzo, Andrea,Sperni, Laura,Fabris, Fabrizio,Scarso, Alessandro

supporting information, (2021/04/12)

An alternative approach is reported for the synthesis of methyl ester protected bisphosphonate building blocks, such as methylene bisphosphonate, vinylidenebisphosphonate and aryl substituted prochiral vinylidenebisphosphonates, that cannot be obtained directly from dimethyl phosphite and dichloromethane.

Diketopyrrolopyrrole Bis-Phosphonate Conjugate: A New Fluorescent Probe for In Vitro Bone Imaging

Chiminazzo, Andrea,Borsato, Giuseppe,Favero, Alessia,Fabbro, Chiara,McKenna, Charles E.,Dalle Carbonare, Luca Giuseppe,Valenti, Maria Teresa,Fabris, Fabrizio,Scarso, Alessandro

supporting information, p. 3617 - 3626 (2019/02/19)

The synthesis of a conjugate molecule between an unusual red-fluorescent diketopyrrolopyrrole (DPP) unit and a bis-phosphonate (BP) precursor by a click-chemistry strategy to target bone tissue and monitor the interaction is reported. After thorough investigation, conjugation through a triazole unit between a γ-azido rather than a β-azido BP and an alkyne-functionalized DPP fluorophore group turned out to be the winning strategy. Visualization of the DPP-BP conjugate on osteoclasts and specific antiresorption activity were successfully demonstrated.

The effect of bisphosphonate acidity on the activity of a thymidylyltransferase

Beaton, Stephen A.,Jiang, Patricia M.,Melong, Jonathan C.,Loranger, Matthew W.,Mohamady, Samy,Veinot, Thomas I.,Jakeman, David L.

supporting information, p. 5473 - 5480 (2013/09/02)

Thymidylyltransferases (thymidine diphospho pyrophosphorylases) are nucleotidylyltransferases that play key roles in the biosynthesis of carbohydrate components within bacterial cell walls and in the biosynthesis of glycosylated natural products. They catalyze the formation of sugar nucleotides concomitant with the release of pyrophosphate. Protein engineering of thymidylyltransferases has been an approach for the production of a variety of non-physiological sugar nucleotides. In this work, we have explored chemical approaches towards modifying the activity of the thymidylyltransferase (Cps2L) cloned from S. pneumoniae, through the use of chemically synthesized 'activated' nucleoside triphosphates with enhanced leaving groups, or by switching the metal ion co-factor specificity. Within a series of phosphonate-containing nucleoside triphosphate analogues, thymidylyltransferase activity is enhanced based on the acidity of the leaving group and a Br?nsted-type analysis indicated that leaving group departure is rate limiting. We have also determined IC50 values for a series of bisphosphonates as inhibitors of thymidylyltransferases. No correlation between the acidity of the inhibitors (pKa) and the magnitude of enzyme inhibition was found. The Royal Society of Chemistry.

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