198470-85-8 Usage
Description
Parecoxib Sodium, a prodrug form of the COX-2 inhibitor Valdecoxib, is a white solid with anti-inflammatory and analgesic properties. It is converted to Valdecoxib by human liver microsomes in vitro and in vivo in various animal models. Additionally, Parecoxib Sodium acts as a cannabinoid (CB) receptor 1 agonist, exhibiting its effects through this receptor as well.
Uses
Used in Pharmaceutical Industry:
Parecoxib Sodium is used as an anti-inflammatory agent for reducing inflammation in various conditions, such as arthritis. Its efficacy is demonstrated in a rat model of M. butyricum-induced arthritis, with an ED50 value of 0.08 mg/kg.
Parecoxib Sodium is also used as an analgesic agent for the management of pain. It has been shown to reduce hyperalgesia in a rat model of carrageenan-induced foot pad edema, with an ED50 value of 5 mg/kg.
Furthermore, Parecoxib Sodium's agonistic activity on the cannabinoid (CB) receptor 1 suggests potential applications in the treatment of conditions related to the endocannabinoid system, although further research may be required to explore these applications fully.
Check Digit Verification of cas no
The CAS Registry Mumber 198470-85-8 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,9,8,4,7 and 0 respectively; the second part has 2 digits, 8 and 5 respectively.
Calculate Digit Verification of CAS Registry Number 198470-85:
(8*1)+(7*9)+(6*8)+(5*4)+(4*7)+(3*0)+(2*8)+(1*5)=188
188 % 10 = 8
So 198470-85-8 is a valid CAS Registry Number.
InChI:InChI=1/C19H18N2O4S.Na/c1-3-17(22)21-26(23,24)16-11-9-14(10-12-16)18-13(2)25-20-19(18)15-7-5-4-6-8-15;/h4-12H,3H2,1-2H3,(H,21,22);/q;+1/p-1
