19857-35-3Relevant articles and documents
One-pot solvent-free synthesis of 2, 3- disubstituted 4(3H)- quinazolinones catalyzed by long-chain double SO3H-functionalized Br?nsted acidic ionic liquids under microwave irradiation
Li, Xinzhong,Lin, Qi,Wang, Lefu
, p. 897 - 901 (2015)
A solvent-free approach for synthesis of 2, 3-disubstituted 4(3H)-quinazolinones by condensation of anthranilic acid with acyl chlorides and aromatic/aliphatic amines using two long chain double SO3H-functionalized acdic ionic liquids as catalyst under microwave irradiation was reported. Under optimized conditions, the reactions completed within 4-8 min and gave the target compounds in the yields of 76-94 %. Two ionic liquids could be recovered readily and recycled three times without any significant loss in their catalytic activity.
Method for selectively synthesizing polysubstituted dihydroquinazolinone or quinazolinone
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Paragraph 0078-0082, (2019/11/12)
The invention discloses a method for selectively synthesizing polysubstituted dihydroquinazolinone or quinazolinone. According to the method, heteropolyacid ion liquid is taken as a catalyst, microwave heating and solvent-free synthesis technologies are utilized, and dihydroquinazolinone and quinazolinone derivatives are selectively synthesized through a 'one-pot-method' synthetic strategy with isatoic anhydride or derivatives of the isatoic anhydride, amine and aldehyde as raw materials. Compared with the prior art, the method has the multiple advantages that the efficiency is high, the costis low, environmental friendliness is realized, reaction selectivity is good, the product yield is high, selective synthesis can be realized, the catalyst is convenient to recover and apply, operationis easy, and industrial mass production is convenient, and the method is an environment-friendly efficient selective synthesis novel method and meets the environment-friendly and chemical developmentidea.
Design, synthesis and pharmacological evaluation of 2-phenyl quinazolin-4-one derivatives as anticolorectal cancer and anti-inflammatory agent
Bosco, Deena,Balakrishnan, Ashitha,Mishra, Rohan,Aneesh
, p. 2677 - 2685 (2018/11/20)
Quinazoline derivatives are heterocyclic compounds that acts as important structural lead for the discovery of effective therapeutic agents. The anti-inflammatory activity along with cytotoxicity helps to reduce the inflammation and pain associated with carcinoma. Derivatives of quinazoline-4-one were preliminary screened and in silico molecular modelling studies using Autodock were performed. In the docking study, ligands were docked against anticancer and anti-inflammatory targets. In silico analysis revealed that the compounds with aromatic substitution at 3rd and halogen substitution at 6th or 7th positions possess lesser side effects and have more potent antitumor activity. Based upon these results 12 compounds were selected, synthesized, characterized and screened for their in vitro, anti-inflammatory, antioxidant and anticancer activities. From the in vitro studies, compounds QA4, QA7 and QB1 showed good anticancer, anti-inflammatory and antioxidant activity when compared to the standard.
