19857-37-5

Basic information

• Product Name: 4(3H)-Quinazolinone, 2-phenyl-3-(phenylmethyl)-
• CAS NO: 19857-37-5
• Molecular Formula: C21H16N2O
• Molecular Weight: 312.371
• Mol File: 19857-37-5.mol
• Article Data: 40

Chemical Properties

• CAS DataBase Reference: 4(3H)-Quinazolinone, 2-phenyl-3-(phenylmethyl)-(CAS DataBase Reference)
• NIST Chemistry Reference: 4(3H)-Quinazolinone, 2-phenyl-3-(phenylmethyl)-(19857-37-5)
• EPA Substance Registry System: 4(3H)-Quinazolinone, 2-phenyl-3-(phenylmethyl)-(19857-37-5)

Safety Data

• Hazardous Substances Data: 19857-37-5(Hazardous Substances Data)

Upstream product

• 1022-46-4 2-phenyl-4H-3,1-benzoxazin-4-one 
• 100-46-9 benzylamine 
• 37716-10-2 4-Benzyl-3,5-diphenyl-4,5-dihydro-1,2,4-oxadiazole 
• 1437798-67-8 C₂₁H₁₇⁽²⁾HN₂O 
• 698-16-8 benzohydroximoyl chloride 
• 780-25-6 N-benzylidene benzylamine 
• 5471-20-5 2-amino-N-benzylbenzamide 
• 118-48-9 isatoic anhydride 
• 611-71-2 MANDELIC ACID 
• 1347035-20-4 N-benzyl-2-(benzylamino)benzamide 
• 611-73-4 Benzoylformic acid 
• 1253935-18-0 C₂₁H₁₈N₄O 
• 100-47-0 benzonitrile 
• 82082-50-6 N-benzyl-2-bromobenzamide 

Downstream Products

• 1022-45-3 2-phenyl-4(3H)-quinazolinone 

Relevant articles and documents

Cu/Pd-catalyzed C-2-H arylation of quinazolin-4(3H)-ones with (hetero)aryl halides

The regiospecific C-2-H arylation of N-3-substituted quinazolin-4(3H)-ones with a wide range of aryl or (hetero)aryl halides under microwave irradiation was studied. A ligand-dependent palladium/copper bicatalytic system was developed and allowed direct c

Efficient one-pot tandem synthesis and cytotoxicity evaluation of 2,3-disubstituted quinazolin-4(3H)-one derivatives

Twenty 2,3-disubstituted quinazolin-4(3H)-one derivatives 1–20 were successfully synthesized in moderate to good yields (25–82%). Their syntheses were based on a one pot tandem ring opening procedure followed by iodine-catalyzed oxidative cyclization of isatoic anhydride with aldehydes, using water as the only solvent under both classical and microwave irradiation conditions. Cytotoxicity assays of the prepared compounds against three human cancer cell lines (HeLa, MCF-7, and A549) indicated that 2, 3, and 20 possessed moderate activities against MCF-7 cells (IC50 = 47.2 μM, 43.9 μM, and 44.9 μM, respectively). Good cytotoxic activities against A549 cells were observed for 3 and 8 with IC50 values of 30.7 μM and 29.8 μM, respectively, which were comparable to the positive control, 5-fluorouracil (5-FU, IC50 = 27.9 μM). Furthermore, compound 4 exhibited slightly stronger activity (IC50 = 23.6 μM) than the positive control 5-FU against the A549 cell line.

One pot synthesis of some new N-allyl and N-benzyl quinazolinones and their anti-inflammatory activity

The simple and more reliable one-pot synthesis of some novel compounds of allyl/Benzyl quinazolinone (4aa-4bd) with good yields from readily available derivatives of anthranilic acid and benzoyl chloride was also reported. Interestingly, as compared to Di