198641-56-4

Basic information

• Product Name: ethyl (2R,4R)-4-methyl-1-((S)-1-phenylethyl)tetrahydropyridine-2-carboxylate
• Synonyms: ethyl (2R,4R)-4-methyl-1-((S)-1-phenylethyl)tetrahydropyridine-2-carboxylate
• CAS NO: 198641-56-4
• Molecular Weight: 275.391
• Mol File: 198641-56-4.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: ethyl (2R,4R)-4-methyl-1-((S)-1-phenylethyl)tetrahydropyridine-2-carboxylate(CAS DataBase Reference)
• NIST Chemistry Reference: ethyl (2R,4R)-4-methyl-1-((S)-1-phenylethyl)tetrahydropyridine-2-carboxylate(198641-56-4)
• EPA Substance Registry System: ethyl (2R,4R)-4-methyl-1-((S)-1-phenylethyl)tetrahydropyridine-2-carboxylate(198641-56-4)

Safety Data

• Hazardous Substances Data: 198641-56-4(Hazardous Substances Data)

Upstream product

• 37662-06-9 ethyl <(S)-1-phenylethyl>iminoethanoate 
• 2627-86-3 (S)-1-phenyl-ethylamine 
• 139334-63-7 ethyl (2R)-4-methyl-1-((S)-1-phenylethyl)-1,2,3,6-tetrahydropyridine-2-carboxylate 

Downstream Products

• 74892-82-3 ethyl (2R-trans)-4-methylpiperidine-2-carboxylate 

Relevant articles and documents

Synthesis method of argatroban intermediate (2R,4R)-4-methyl piperidine-2-ethyl formate

The invention relates to a synthesis method of an argatroban intermediate (2R,4R)-4-methyl piperidine-2-ethyl formate compound. The synthesis method comprises the following steps: (1) under the action of a rhodium catalyst and ferric oxalate, carrying out catalytic hydrogenation on (2R)-4-methyl-1-((S)-1-phenethyl)-1,2,3,6-tetrahydropyridine-2-ethyl formate, so that (2R,4R)-4-methyl-1-((S)-1-phenethyl)-2-pyridine ethyl formate is obtained; and (2) under the action of a palladium catalyst and ferric oxalate, removing benzyl, so that the (2R,4R)-4-methyl piperidine-2-ethyl formate is obtained. The synthesis method provided by the invention has the advantages that the ferric oxalate is introduced into a reaction system, two-step reaction yield is increased, especially the efficiency is the highest when the ferric oxalate and a rhodium-silicon dioxide catalyst are used together, and the cost is effectively reduced, so that the synthesis method is applicable to industrial production.