19870-47-4Relevant articles and documents
A series of penicillin derived C2-symmetric inhibitors of HIV-1 proteinase: synthesis, mode of interaction, and structure-activity relationships.
Humber,Bamford,Bethell,Cammack,Cobley,Evans,Gray,Hann,Orr,Saunders,et al.
, p. 3120 - 3128 (2007/10/02)
The C2-symmetric diester 1 was identified by random screening as a novel inhibitor of HIV-1 proteinase. This led to the preparation of a series of related more potent amides from readily accessible penicillins. Many of the compounds showed potent antivira
Studies related to Penicillins. Part 20. The Mechanism of the Rearangement of Methyl Benzylpenicillinate to Methyl Benzylpenillonate
Sharma, Rajiv,Stoodley, Richard J.
, p. 2001 - 2008 (2007/10/02)
In boiling benzene containing a trace of iodine, methyl benzylpenicillinate (1) isomerises to methyl benzylpenillonate (10a).The rearrangement is triggered by a 4,7-bond cleavage of the penicillinate (1a) and probably involves the formation of methyl (4S)