198712-64-0 Usage
Description
4-HYDROXYACETOPHENONE OXIME, also known as (1E)-1-(4-Hydroxyphenyl)ethanone Oxime, is an organic compound that serves as an impurity compound of Paracetamol. It is characterized by its oxime functional group and hydroxyl group attached to an acetophenone structure, which grants it unique chemical properties and potential applications in various fields.
Uses
Used in Pharmaceutical Industry:
4-HYDROXYACETOPHENONE OXIME is used as an intermediate in the synthesis of various pharmaceutical compounds. Its role in the regeneration of carbonyl compounds from oximes is particularly significant in the context of Paracetamol production, where it contributes to the overall efficiency and quality of the final product.
Used in Chemical Synthesis:
In the field of chemical synthesis, 4-HYDROXYACETOPHENONE OXIME is utilized as a key intermediate for the preparation of different organic compounds. Its unique structure allows for further functionalization and modification, making it a versatile building block in the synthesis of various molecules with potential applications in pharmaceuticals, agrochemicals, and other industries.
Used in Research and Development:
4-HYDROXYACETOPHENONE OXIME also finds application in research and development, where it is employed as a model compound to study the reactivity and properties of oxime-containing molecules. This helps in understanding the underlying mechanisms of various chemical reactions and can lead to the discovery of new synthetic routes and applications for related compounds.
Check Digit Verification of cas no
The CAS Registry Mumber 198712-64-0 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,9,8,7,1 and 2 respectively; the second part has 2 digits, 6 and 4 respectively.
Calculate Digit Verification of CAS Registry Number 198712-64:
(8*1)+(7*9)+(6*8)+(5*7)+(4*1)+(3*2)+(2*6)+(1*4)=180
180 % 10 = 0
So 198712-64-0 is a valid CAS Registry Number.
198712-64-0Relevant articles and documents
Dehydrative Beckmann rearrangement and the following cascade reactions
Liu, Yinghui,Wei, Yongjiao,Xie, Lan-Gui
supporting information, (2021/11/16)
The Beckmann rearrangement has been predominantly studied for the synthesis of amide and lactam. By strategically using the in situ generated Appel's salt or Mitsunobu's zwitterionic adduct as the dehydrating agent, a series of Beckmann rearrangement and following cascade reactions have been developed herein. The protocol allows the conversion of various ketoximes into amide, thioamide, tetrazole and imide products in modular procedures. The generality and tolerance of functionalities of this method have been demonstrated.
A mild system for synthesis of aldoximes and ketoximes in the presence of N-hydroxyphthalimide in aqueous system
Jiang, Xiaoying,Xu, Xiaohe,Lin, Yuyan,Yan, Yiyan,Li, Pingping,Bai, Renren,Xie, Yuanyuan
supporting information, p. 5879 - 5885 (2018/09/06)
An efficient method for synthesis of oximes from aldehydes or ketones with N-hydroxyphthalimide or N-hydroxysuccinimide in water has been described. It is the first time to utilize NHPI as an oximation reagent to synthesize aldoximes and ketoximes from the corresponding organic carbonyl compounds without other reagents. The reaction tolerates various functional groups and affords the corresponding oximes in 76%–98% yields. The by-product phthalic acid can be recycled from the system. In addition, this method has been successfully applied to the synthesis of the precursor of some pharmacologically active amide molecules.
Regioselective synthesis of syn-oximes using 3A molecular sieves in a solventless system
Bigdeli, Mohammad A.,Nikje, Mir.M.Alavi,Jafari, Said,Heravi, Majid M.
, p. 20 - 21 (2007/10/03)
Regioselective synthesis of syn-oximes using 3A molecular sieves under solvent-free condition is described.
