198836-50-9

Basic information

• Product Name: N-(2-nitrobenzenesulfonyl)-L-serine methyl ester
• Synonyms: N-(2-nitrobenzenesulfonyl)-L-serine methyl ester
• CAS NO: 198836-50-9
• Molecular Weight: 304.28
• Mol File: 198836-50-9.mol
• Article Data: 4

Chemical Properties

• CAS DataBase Reference: N-(2-nitrobenzenesulfonyl)-L-serine methyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: N-(2-nitrobenzenesulfonyl)-L-serine methyl ester(198836-50-9)
• EPA Substance Registry System: N-(2-nitrobenzenesulfonyl)-L-serine methyl ester(198836-50-9)

Safety Data

• Hazardous Substances Data: 198836-50-9(Hazardous Substances Data)

Upstream product

• 5680-80-8 methyl (2S)-2-amino-3-hydroxypropanoate hydrochloride 
• 1694-92-4 2-Nitrobenzenesulfonyl chloride 
• 2788-84-3 (S)-serine methyl ester 

Downstream Products

• 369617-56-1 N-methyl-N-(2-nitrobenzenesulfonyl)-L-serine methyl ester 
• 2788-84-3 (S)-serine methyl ester 
• 369617-57-2 N-(2-aminobenzenesulfonyl)-N-methyl-L-serine methyl ester 

Relevant articles and documents

Kras inhibitory cyclic peptide compound

The following were discovered: a cyclic peptide compound that interacts with Ras; and an unnatural amino acid that is useful in the production of said cyclic peptide compound. The cyclic peptide compound was also discovered to inhibit bonding between Ras and SOS. The following were additionally discovered: a specific unnatural amino acid included in said cyclic peptide compound; and a manufacturing method therefor.

N-monoalkylation of α-amino acid esters under solid-liquid PTC conditions

N-(2-Nitrophenylsulfonyl)- (o-NBS-AA-OMe, 4) and N-(4- Nitrophenylsulfonyl)-α-amino acid methyl esters (p-NBSAA-OMe, 5) were N- alkylated with a variety of alkyl halides 6 under solid-liquid phase-transfer catalysis (SL-PTC) conditions, affording the alkylated products o-NBS-N-R2- AA-OMe 7 and p-NBS-N-R2-AA-OMe 8 in excellent yields without any detectable racemization.