198904-22-2

Basic information

• Product Name: methyl [(1S,4S,5S,10S)-4-benzyl-5-hydroxy-1,10-bis(1-methylethyl)-2,9,12-trioxo-7-(4-pyridin-2-ylbenzyl)-13-oxa-3,7,8,11-tetraazatetradec-1-yl]carbamate (non-preferred name)
• Synonyms: butanoic acid, 2-[(methoxycarbonyl)amino]-3-methyl-, 2-[(2S,3S)-2-hydroxy-3-[[(2S)-2-[(methoxycarbonyl)amino]-3-methyl-1-oxobutyl]amino]-4-phenylbutyl]-2-[[4-(2-pyridinyl)phenyl]methyl]hydrazide, (2S)-; methyl {(5S,10S,11S,14S)-11-benzyl-10-hydroxy-15-methyl-3,6,13-trioxo-5-(propan-2-yl)-8-[4-(pyridin-2-yl)benzyl]-2-oxa-4,7,8,12-tetraazahexadecan-14-yl}carbamate
• CAS NO: 198904-22-2
• Molecular Formula: C₃₆H₄₈N₆O₇
• Molecular Weight: 676.8023
• Mol File: 198904-22-2.mol
• Article Data: 2

Chemical Properties

• Density: 1.196g/cm³
• Refractive Index: 1.566
• CAS DataBase Reference: methyl [(1S,4S,5S,10S)-4-benzyl-5-hydroxy-1,10-bis(1-methylethyl)-2,9,12-trioxo-7-(4-pyridin-2-ylbenzyl)-13-oxa-3,7,8,11-tetraazatetradec-1-yl]carbamate (non-preferred name)(CAS DataBase Reference)
• NIST Chemistry Reference: methyl [(1S,4S,5S,10S)-4-benzyl-5-hydroxy-1,10-bis(1-methylethyl)-2,9,12-trioxo-7-(4-pyridin-2-ylbenzyl)-13-oxa-3,7,8,11-tetraazatetradec-1-yl]carbamate (non-preferred name)(198904-22-2)
• EPA Substance Registry System: methyl [(1S,4S,5S,10S)-4-benzyl-5-hydroxy-1,10-bis(1-methylethyl)-2,9,12-trioxo-7-(4-pyridin-2-ylbenzyl)-13-oxa-3,7,8,11-tetraazatetradec-1-yl]carbamate (non-preferred name)(198904-22-2)

Safety Data

• Hazardous Substances Data: 198904-22-2(Hazardous Substances Data)

Upstream product

• 1313358-78-9 1-[4-(pyridin-2-yl)-phenyl]-4(S)-hydroxy-5(S)-2,5-diamino-6-phenyl-2-azahexane hydrochloride 
• 111398-44-8 N-methoxycarbonyl-L-valine 
• 857904-11-1 N-(tert-butoxycarbonyl)-N'-[4-(pyridin-2-yl)phenylmethylidene]hydrazine 
• 198904-85-7 N-1-(tert-butoxycarbonyl)-N-2-[4-(pyridine-2-yl)benzyl]hydrazine 
• 24856-58-4 1,1-dimethoxy-1-(4-bromophenyl)methane 
• 127406-56-8 4-(2'-pyridyl)benzaldehyde 
• 109-04-6 2-bromo-pyridine 
• 198904-87-9 1-[4-(pyridin-2-yl)phenyl]-4(S)-hydroxy-5(S)-2,5-diamino-6-phenyl-2-azahexane trihydrochloride 
• 198904-86-8 1-[4-(pyridine-2-yl)phenyl]-5(S)-2,5-bis[(tert-butyloxycarbonyl)amino]-4(S)-hydroxy-6-phenyl-2-azahexane 

Relevant articles and documents

ANTIVIRALLY ACTIVE HETEROCYCLIC AZAHEXANE DERIVATIVES

There are described compounds of formula I*, STR1 wherein R. sub.1 is lower alkoxycarbonyl,R 2 is secondary or tertiary lower alkyl or lower alkylthio-lower alkyl, R. sub.3 is phenyl that is unsubstituted or substituted by one or more lower alkoxy radicals, or C 4-C 8 cycloalkyl,R. sub.4 is phenyl or cyclohexyl each substituted in the 4-position by unsaturated heterocyclyl that is bonded by way of a ring carbon atom, has from 5 to 8 ring atoms, contains from 1 to 4 hetero atoms selected from nitrogen, oxygen, sulfur, sulfinyl (--SO--) and sulfonyl (--SO 2--) and is unsubstituted or substituted by lower alkyl or by phenyl-lower alkyl,R 5, independently of R 2, has one of the meanings mentioned for R 2, andR 6, independently of R. sub.1, is lower alkoxycarbonyl,or salts thereof, provided that at least one salt-forming group is present. The compounds are inhibitors of retroviral aspartate protease and can be used, for example, in the treatment of AIDS. They exhibit outstanding pharmacodynamic properties.