198969-19-6

Basic information

• Product Name: (2R,4R)-4-Phenoxy-1,2-pyrrolidinedicarboxylic acid1-(1,1-dimethylethyl)-2-methylester
• Synonyms: (2R,4R)-4-Phenoxy-1,2-pyrrolidinedicarboxylic acid1-(1,1-dimethylethyl)-2-methylester;1,2-Pyrrolidinedicarboxylic acid, 4-phenoxy-, 1-(1,1-diMethylethyl) 2-Methyl ester, (2R,4R)-;(2R,4R)-1-Boc-2-Methyl-4-phenoxypyrrolidine-2-carboxylic acid
• CAS NO: 198969-19-6
• Molecular Formula: C₁₇H₂₃NO₅
• Molecular Weight: 321.36822
• Mol File: 198969-19-6.mol
• Article Data: 2

Chemical Properties

• Boiling Point: 411.654°C at 760 mmHg
• Flash Point: 202.761°C
• Appearance: /
• Density: 1.173g/cm³
• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.526
• CAS DataBase Reference: (2R,4R)-4-Phenoxy-1,2-pyrrolidinedicarboxylic acid1-(1,1-dimethylethyl)-2-methylester(CAS DataBase Reference)
• NIST Chemistry Reference: (2R,4R)-4-Phenoxy-1,2-pyrrolidinedicarboxylic acid1-(1,1-dimethylethyl)-2-methylester(198969-19-6)
• EPA Substance Registry System: (2R,4R)-4-Phenoxy-1,2-pyrrolidinedicarboxylic acid1-(1,1-dimethylethyl)-2-methylester(198969-19-6)

Safety Data

• Hazardous Substances Data: 198969-19-6(Hazardous Substances Data)

Usage

Description

(2R,4R)-4-Phenoxy-1,2-pyrrolidinedicarboxylic acid 1-(1,1-dimethylethyl)-2-methylester, also known as Ramipril, is a medication belonging to the class of angiotensin-converting enzyme (ACE) inhibitors. It is used to treat high blood pressure and heart failure by relaxing blood vessels and reducing the workload on the heart. Ramipril works by inhibiting the ACE enzyme, which causes the body to retain fluid and constrict blood vessels. By blocking this enzyme, Ramipril helps to lower blood pressure and improve the heart's ability to pump blood effectively. It is typically taken orally in the form of a tablet and is available by prescription only.

Uses

Used in Pharmaceutical Industry:
Ramipril is used as an antihypertensive and heart failure treatment for managing high blood pressure and improving the heart's ability to pump blood effectively. It functions by inhibiting the ACE enzyme, leading to relaxation of blood vessels and reduced fluid retention in the body.
Common side effects of Ramipril include dizziness, cough, and increased blood potassium levels. It is important to consult a healthcare professional before using this medication, as it may interact with other drugs or medical conditions.

InChI:InChI=1/C17H23NO5/c1-17(2,3)23-16(20)18-11-13(10-14(18)15(19)21-4)22-12-8-6-5-7-9-12/h5-9,13-14H,10-11H2,1-4H3/t13-,14-/m1/s1

Upstream product

• 135042-17-0 (2R,4S)-1-tert-butyl 2-methyl 4-hydroxypyrrolidine-1,2-dicarboxylate 
• 108-95-2 phenol 

Downstream Products

• 198968-94-4 (2R,4R)-4-Phenoxy-pyrrolidine-2-carboxylic acid methyl ester 
• 198968-77-3 (2R,4R)-1-[2-(Adamantan-2-yloxycarbonylamino)-3-(1H-indol-3-yl)-2-methyl-propionyl]-4-phenoxy-pyrrolidine-2-carboxylic acid methyl ester 

Relevant articles and documents

PYRROLIDINE GPR40 MODULATORS

The present invention provides compounds of Formula (I): or a stereoisomer, or a pharmaceutically acceptable salt thereof, wherein all of the variables are as defined herein. These compounds are GPR40 G protein-coupled receptor modulators which may be used as medicaments.