198976-06-6 Usage
Description
DIHYDRO-ARTEMISININ GLUCURONIDE is a metabolite of Dihydro Artemisinin, which is a derivative of the Artemisinin compound found in the sweet wormwood plant (Artemisia annua). It is a white solid with potent antimalarial properties, making it a crucial component in the fight against malaria.
Uses
Used in Pharmaceutical Industry:
DIHYDRO-ARTEMISININ GLUCURONIDE is used as an antimalarial agent for its ability to effectively treat and prevent malaria infections. It is particularly valuable due to its rapid action against the Plasmodium parasite, which is responsible for causing malaria.
Used in Research and Development:
In the field of research and development, DIHYDRO-ARTEMISININ GLUCURONIDE serves as a key compound for studying the mechanisms of action and potential applications of Artemisinin and its derivatives. This helps in the development of new drugs and therapies for various diseases, including malaria and other parasitic infections.
Used in Public Health Initiatives:
DIHYDRO-ARTEMISININ GLUCURONIDE is utilized in public health initiatives aimed at reducing the global burden of malaria. It is an essential component in the formulation of artemisinin-based combination therapies (ACTs), which are the current standard of treatment for uncomplicated malaria in many regions.
Used in Drug Resistance Studies:
As a metabolite of Dihydro Artemisinin, DIHYDRO-ARTEMISININ GLUCURONIDE plays a role in studying drug resistance in Plasmodium parasites. Understanding the resistance mechanisms can help in the development of new strategies to combat the evolving challenges posed by drug-resistant malaria strains.
Check Digit Verification of cas no
The CAS Registry Mumber 198976-06-6 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,9,8,9,7 and 6 respectively; the second part has 2 digits, 0 and 6 respectively.
Calculate Digit Verification of CAS Registry Number 198976-06:
(8*1)+(7*9)+(6*8)+(5*9)+(4*7)+(3*6)+(2*0)+(1*6)=216
216 % 10 = 6
So 198976-06-6 is a valid CAS Registry Number.
InChI:InChI=1/C21H32O11/c1-8-4-5-11-9(2)17(28-18-14(24)12(22)13(23)15(27-18)16(25)26)29-19-21(11)10(8)6-7-20(3,30-19)31-32-21/h8-15,17-19,22-24H,4-7H2,1-3H3,(H,25,26)/t8-,9-,10+,11+,12+,13+,14+,15?,17?,18+,19-,20-,21-/m1/s1
198976-06-6Relevant articles and documents
Efficient preparations of the β-glucuronides of dihydroartemisinin and structural confirmation of the human glucuronide metabolite
O'Neill,Scheinmann,Stachulski,Maggs,Park
, p. 1467 - 1470 (2001)
New and greatly improved preparations of the 12α, 1′β- (5) and 12β,1′β- (6) glucuronides of dihydroartemisinin (DHA, 2) are reported using anomeric hydroxy and imidate glucuronate intermediates. Comparison of the synthetic and natural materials shows that
