1991-79-3

Basic information

• Product Name: 2-AMINO-3-(2-BROMO-PHENYL)-PROPIONIC ACID
• Synonyms: 2-AMINO-3-(2-BROMO-PHENYL)-PROPIONIC ACID;2-BROMO-DL-PHENYLALANINE;DL-2-Bromophenylalanine;2-Bromophenylalanine
• CAS NO: 1991-79-3
• Molecular Formula: C₉H₁₀BrNO₂
• Molecular Weight: 244.09
• Mol File: 1991-79-3.mol
• Article Data: 5

Chemical Properties

• Boiling Point: 363.2 °C at 760 mmHg
• Flash Point: 173.4 °C
• Appearance: /
• Density: 1.588 g/cm³
• Vapor Pressure: 6.53E-06mmHg at 25°C
• Refractive Index: 1.608
• Storage Temp.: Keep in dark place,Inert atmosphere,Room temperature
• PKA: 2.16±0.10(Predicted)
• CAS DataBase Reference: 2-AMINO-3-(2-BROMO-PHENYL)-PROPIONIC ACID(CAS DataBase Reference)
• NIST Chemistry Reference: 2-AMINO-3-(2-BROMO-PHENYL)-PROPIONIC ACID(1991-79-3)
• EPA Substance Registry System: 2-AMINO-3-(2-BROMO-PHENYL)-PROPIONIC ACID(1991-79-3)

Safety Data

• Hazardous Substances Data: 1991-79-3(Hazardous Substances Data)

Usage

Description

2-AMINO-3-(2-BROMO-PHENYL)-PROPIONIC ACID, also known as 2-Bromo-DL-phenylalanine, is an organic compound with the molecular formula C9H10BrNO2. It is a derivative of phenylalanine, an essential amino acid, where a bromine atom is attached to the second carbon of the phenyl ring. This modification introduces unique chemical and biological properties to the molecule, making it a versatile building block in various synthetic and pharmaceutical applications.

Uses

Used in Pharmaceutical Industry:
2-AMINO-3-(2-BROMO-PHENYL)-PROPIONIC ACID is used as a reactant for the stereoselective preparation of isoquinoline-substituted secondary amines. These secondary amines are important intermediates in the synthesis of various pharmaceutical compounds, including those with potential applications in the treatment of neurological disorders, pain management, and other therapeutic areas.
Used in Chemical Synthesis:
In the field of chemical synthesis, 2-AMINO-3-(2-BROMO-PHENYL)-PROPIONIC ACID serves as a key building block for the creation of novel molecules with specific biological activities. Its unique structure allows for further functionalization and modification, making it a valuable component in the development of new drugs and other bioactive molecules.
Used in Research and Development:
2-AMINO-3-(2-BROMO-PHENYL)-PROPIONIC ACID is also utilized in research and development settings, where it can be employed to study the effects of structural modifications on the biological activity of molecules. This knowledge can be applied to optimize the design of new compounds with improved pharmacological properties and reduced side effects.

InChI:InChI=1/C9H10BrNO2/c10-7-4-2-1-3-6(7)5-8(11)9(12)13/h1-4,8H,5,11H2,(H,12,13)

Upstream product

• 58380-12-4 <(2-bromophenyl)methyl>propanedicarboxylic acid 
• 120667-45-0 diethyl (acetylamino)<(2-bromophenyl)methyl>propanedioate 
• 7345-79-1 2-bromocinnamic acid 

Downstream Products

• 42538-40-9 (S)-2-amino-3-(2-bromophenyl)propanoic acid 
• 135334-92-8 2-bromo-N-(methoxycarbonyl)phenylalanine 
• 917247-85-9 rac-3-(2-bromophenyl)-2-hydroxypropionic acid 
• 123098-44-2 Z-DL-Phe(2Br) 
• 267225-27-4 (2R)-2-amino-3-(2-bromophenyl)propanoic acid 
• 261165-02-0 3-(2-bromophenyl)-2-((tert-butoxycarbonyl)amino)propanoic acid 
• 256474-48-3 Z-(RS)-Phe(2Br)-OMe 
• 203640-55-5 Z-(RS)-Phe(2Br)-OCH₂CF₃ 

Relevant articles and documents

Bi-enzymatic Conversion of Cinnamic Acids to 2-Arylethylamines

The conversion of carboxylic acids, such as acrylic acids, to amines is a transformation that remains challenging in synthetic organic chemistry. Despite the ubiquity of similar moieties in natural metabolic pathways, biocatalytic routes seem to have been overlooked for this purpose. Herein we present the conception and optimisation of a two-enzyme system, allowing the synthesis of β-phenylethylamine derivatives from readily-available ring-substituted cinnamic acids. After characterisation of both parts of the reaction in a two-step approach, a set of conditions allowing the one-pot biotransformation was optimised. This combination of a reversible deaminating and irreversible decarboxylating enzyme, both specific for the amino acid intermediate in tandem, represents a general method by which new strategies for the conversion of carboxylic acids to amines could be designed.

Lyaseenzymes, Nucleic Acids Encoding Them and Methods For Making and Using Them

This invention provides polypeptides having lyase activity, polynucleotides encoding these polypeptides, and meth-°ds of making and using these polynucleotides and polypeptides. In one aspect, the invention is directed to polypeptides having ammonia lyase activity, e.g., phenylalanine ammonia lyase, tyrosine ammonia lyase and/or histidine ammonia lyase activity, including thermostable and thermotolerant activity, and polynucleotides encoding these enzymes, and making and using these polynucleotides and polypeptides. The polypeptides of the invention can be used in a variety of pharmaceutical, agricultural and industrial contexts. X═NO2, Cl, Br, NH2, OH, H, alkyl at one or several o, m, and p positions R═H or alkyl.

Substituted carboxytetrahydroisoquinolines and derivatives thereof having pharmaceutical activity

The invention includes a novel series of substituted aryl or heteroaryl fused 2- or 6-carboxy piperidines and derivatives thereof which are useful in the treatment of cerebrovascular disorders, epilepsy, Huntington's disease, or as anesthetics particularly in surgical processes where a finite risk of cerebrovascular damage exists. Processes for making the compounds, novel intermediates useful in the processes, methods for using, and compositions containing the compounds are also included.