199114-62-0

Basic information

• Product Name: 2-(CHLOROMETHYL)-3-METHYLQUINAZOLIN-4(3H)-ONE
• Synonyms: 2-(CHLOROMETHYL)-3-METHYLQUINAZOLIN-4(3H)-ONE;2-(chloroMethyl)-3-Methyl-3,4-dihydroquinazolin-4- one;2-(ChloroMethyl)-3-Methylquinazoline-4(3H)-one
• CAS NO: 199114-62-0
• Molecular Formula: C₁₀H₉ClN₂O
• Molecular Weight: 208.64
• Mol File: 199114-62-0.mol
• Article Data: 8

Chemical Properties

• Melting Point: 185 °C(Solv: isopropanol (67-63-0))
• Boiling Point: 337.4±44.0 °C(Predicted)
• Appearance: /
• Density: 1.32±0.1 g/cm3(Predicted)
• Storage Temp.: 2-8°C
• PKA: 0.88±0.70(Predicted)
• CAS DataBase Reference: 2-(CHLOROMETHYL)-3-METHYLQUINAZOLIN-4(3H)-ONE(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(CHLOROMETHYL)-3-METHYLQUINAZOLIN-4(3H)-ONE(199114-62-0)
• EPA Substance Registry System: 2-(CHLOROMETHYL)-3-METHYLQUINAZOLIN-4(3H)-ONE(199114-62-0)

Safety Data

• Hazard Codes: Xn
• Statements: 22-36-52
• Safety Statements: 26
• Hazardous Substances Data: 199114-62-0(Hazardous Substances Data)

Usage

General Description

2-(Chloromethyl)-3-methylquinazolin-4(3H)-one is a chemical compound with the molecular formula C10H9ClN2O. It is a quinazolinone derivative with a chloromethyl group and a methyl group attached to the quinazoline ring. 2-(CHLOROMETHYL)-3-METHYLQUINAZOLIN-4(3H)-ONE has potential pharmacological activity due to its quinazolinone structure, which has been studied for its potential as an antitumor agent. It may also have other biological activities that have not yet been fully explored. 2-(CHLOROMETHYL)-3-METHYLQUINAZOLIN-4(3H)-ONE is of interest to researchers in the fields of medicinal chemistry and drug discovery due to its potential therapeutic applications.

Upstream product

• 53824-91-2 2-ω-chloroacetylamino-N-methylbenzamide 
• 4141-08-6 2-Amino-N-methylbenzamid 
• 77-78-1 dimethyl sulfate 
• 3817-05-8 2-(chloromethyl)quinazolin-4(3H)-one 
• 118-48-9 isatoic anhydride 
• 79-04-9 chloroacetyl chloride 
• 74-89-5 methylamine 
• 21721-78-8 2-ω-chloroacetylaminobenzamide 
• 28144-70-9 anthranilic acid amide 

Downstream Products

• 228871-35-0 2-[(4-bromo-phenylamino)-methyl]-3-methyl-3H-quinazolin-4-one 
• 1182294-10-5 2-[(4-fluorophenylsulfonyl)methyl]-3-methylquinazolin-4(3H)-one 
• 1182294-08-1 2-[(4-chlorophenylsulfonyl)methyl]-3-methylquinazolin-4(3H)-one 
• 1182294-04-7 3-methyl-2-(phenylsulfonylmethyl)quinazolin-4(3H)-one 
• 1182294-07-0 3-methyl-2-(tosylmethyl)quinazolin-4(3H)-one 
• 1182294-12-7 2-[(4-bromophenylsulfonyl)methyl]-3-methylquinazolin-4(3H)-one 
• 1182294-16-1 3-methyl-2-[(3-nitrophenylsulfonyl)methyl]-3-methylquinazolin-4(3H)-one 
• 1182294-14-9 3-methyl-2-[(4-nitrophenylsulfonyl)methyl]-3-methylquinazolin-4(3H)-one 

Relevant articles and documents

Synthesis and preliminary structure-activity relationship study of 3-methylquinazolinone derivatives as EGFR inhibitors with enhanced antiproliferative activities against tumour cells

In this paper, a set of 3-methylquniazolinone derivatives were designed, synthesised, and studied the preliminary structure-activity relationship for antiproliferative activities. All target compounds performed significantly inhibitory effects against wil

Design, synthesis and in vitro biological evaluation of quinazolinone derivatives as EGFR inhibitors for antitumor treatment

In this paper, a series of novel 3-methyl-quinazolinone derivatives was designed, synthesised and evaluated for antitumor activity in vitro on wild type epidermal growth factor receptor tyrosine kinase (EGFRwt-TK) and three human cancer cell li

Synthesis of benzoxazolthiolyl and benzthiazolthiolyl fused 3- alkylquinazolin-4(3H)-ones

Condensation of anthranilamide (1) with chloroacetyl chloride for 1 hr at RT gave 2- (2-chloroacetamido) benzamide (2). The latter, on refluxation in acetic acid for 2 hr gave 2-(chloromethyl) quinazolin-4(3H)-one (3). Condensation of 3, independently, with each one of benz [d] oxazole-2-thiol (4a) and benz [d] thiazole-2-thiol (4b), for 3-4 hr, gave 2-((benz [d] oxazol-2-ylthio) methyl) quinazolin-4(3H)-one (5a) and 2-((benz [d] thiazol-2-ylthio) methyl) quinazolin-4(3H)-one (5b) respectively. Each one of the 5a and 5b, independently and selectively, when treated with alkylating agents (i.e. DMS, DES, PhCH2Cl), gave 2-((benz [d] oxazol-2-ylthio) methyl)-3-alkylquinazolin-4(3H)-ones (6a-c) and 2-((benz [d] thiazol-2-ylthio) methyl)-3-alkylquinazolin-4(3H)-ones (6d-f) respectively. The latter 6a-f could also be prepared, alternatively, by condensing chloromethyl-3-alkylquinazolin-4(3H)-one (7a-c) with 4a-b respectively, in good yields.