199168-51-9

Basic information

• Product Name: (2-(4-methoxyphenyl)-6-methylquinoline)
• Synonyms: (2-(4-methoxyphenyl)-6-methylquinoline)
• CAS NO: 199168-51-9
• Molecular Weight: 249.312
• Mol File: 199168-51-9.mol
• Article Data: 7

Chemical Properties

• CAS DataBase Reference: (2-(4-methoxyphenyl)-6-methylquinoline)(CAS DataBase Reference)
• NIST Chemistry Reference: (2-(4-methoxyphenyl)-6-methylquinoline)(199168-51-9)
• EPA Substance Registry System: (2-(4-methoxyphenyl)-6-methylquinoline)(199168-51-9)

Safety Data

• Hazardous Substances Data: 199168-51-9(Hazardous Substances Data)

Upstream product

• 91-62-3 6-methylquinoline 
• 14774-77-7 p-methoxyphenyllithium 
• 106-49-0 p-toluidine 
• 123-11-5 4-methoxy-benzaldehyde 
• 74-86-2 acetylene 
• 51410-44-7 1-(4-methoxylphenyl)-2-propen-1-ol 
• 29289-13-2 2-iodo-4-methylaniline 
• 64-17-5 ethanol 
• 112825-69-1 (4-methoxybenzyl)-p-tolylamine 
• 79-24-3 Nitroethane 
• 1963-36-6 4-methoxycinnamaldehyde 

Downstream Products

• 21202-80-2 4-chloro-2-(4-methoxy-phenyl)-6-methyl-quinoline 

Relevant articles and documents

Visible-light-induced photoxidation-Povarov cascade reaction: synthesis of 2-arylquinoline through alcohol andN-benzylanilines under mild conditionsviaAg/g-C3N4nanometric semiconductor catalyst

With a Ag/g-C3N4nanometric semiconductor as the photocatalyst, 2-arylquinolines were synthesized through a photoxidation-Povarov cascade reaction ofN-benzylanilines and alcohols under visible light irradiation. Under the blue light of a 3 W LED, good yields were achieved for various substrates in oxygen at room temperature. This methodology provides a green and mild alternative for the formation of 2-arylquinoline derivatives. Remarkably, the Ag/g-C3N4nanocomposite can be conveniently recovered and reused several times with satisfying yields.

Direct C-H Arylation and Alkylation of Electron-Deficient Heteroaromatic Compounds with Organozinc Reagents

A direct and convenient method for the C-H arylation and alkylation of electron-deficient N-heteroarenes with readily available organozinc reagents has been developed. This transformation could be readily performed in the absence of a transition-metal catalyst and external oxidants, affording a wide range of substituted heteroarenes with good functional group tolerance in good to excellent yields. The developed simple protocol is scalable to the gram level and suitable for late-stage modification of bioactive molecules and drugs.

Iron-Catalyzed Aerobic Dehydrogenative Kinetic Resolution of Cyclic Secondary Amines

A nonenzymatic iron-catalyzed dehydrogenative kinetic resolution of cyclic secondary amines using air as an oxidant has been reported. The economical and practical method is applicable to a series of cyclic benzylic amines, including 5,6-dihydrophenanthridines and 1,2-dihydroquinolines, with diverse functional groups at the α position in high yields with excellent enantioselectivities. The direct dehydrogenative kinetic resolution of advanced intermediates of bioactive molecules that are difficult to access using existing catalytic asymmetric synthetic strategy was also demonstrated.