199177-61-2

Basic information

• Product Name: Pentanenitrile, 3-hydroxy-, (3S)-
• CAS NO: 199177-61-2
• Molecular Formula: C5H9NO
• Molecular Weight: 99.1326
• Mol File: 199177-61-2.mol
• Article Data: 6

Chemical Properties

• CAS DataBase Reference: Pentanenitrile, 3-hydroxy-, (3S)-(CAS DataBase Reference)
• NIST Chemistry Reference: Pentanenitrile, 3-hydroxy-, (3S)-(199177-61-2)
• EPA Substance Registry System: Pentanenitrile, 3-hydroxy-, (3S)-(199177-61-2)

Safety Data

• Hazardous Substances Data: 199177-61-2(Hazardous Substances Data)

Upstream product

• 106-88-7 ethyloxirane 
• 143-33-9 sodium cyanide 
• 108-05-4 vinyl acetate 
• 13635-05-7 3-hydroxyvaleronitrile 
• 713512-28-8 1-(cyanomethyl)propyl butyrate 

Downstream Products

• 589-98-0 (S)-octan-3-ol 

Relevant articles and documents

Enantioselective ring opening of epoxides with cyanide catalysed by halohydrin dehalogenases: A new approach to non-racemic β-hydroxy nitriles

Halohydrin dehalogenases (HheA, HheB and HheC) were found to efficiently catalyse a carbon-carbon bond forming reaction between terminal aliphatic epoxides and cyanide, yielding β-hydroxy nitriles. With all three enzymes nucleophilic ring opening of epoxi

Efficient preparation of (R)-3-hydroxypentanenitrile with high enantiomeric excess by enzymatic reduction with subsequent enhancement of the optical purity by lipase-catalyzed ester hydrolysis

An efficient chemo-enzymatic procedure for the synthesis of (R)-3-hydroxypentanenitrile (1) with over 99% enantiomeric excess using two enzymatic reactions was successfully established. Initial enantioselective enzymatic reduction of 3-oxopentanenitrile with reductase S1 gave (R)-1 with an 81.5% ee which was then converted to (R)-1-(cyanomethyl) propyl n-butyrate (3b). Subsequent lipase-catalyzed enantioselective hydrolysis of 3b gave (R)-1 in a high yield with over 99% ee.

Preparation of novel hydrophobic fluorine-substituted-alkyl sulfate ionic liquids and application as an efficient reaction medium for lipase-catalyzed reaction

Various types of differently fluorinated-alkyl sulfate ionic liquids have been prepared; the hydrophobicity was dependent on the content ratio of the fluorine on the alkyl sulfate anion and 2,2,3,3,4,4,5,5-octafluoropentyl sulfate salts showed hydrophobic properties. Melting point and viscosity were also dependent on the fluorine contents of the anionic part, while conductivity was determined by the cationic part and not influenced by the fluorine contents. Efficient lipase-catalyzed transesterification was demonstrated using hydrophobic 1-butyl-3-methylimidazolim 2,2,3,3,4,4,5,5-octafluoropentyl sulfate ([bmim][C5F8]) as solvent.