199589-50-9

Basic information

• Product Name: 3-(1-{[(2-methoxy-4-methylphenyl)sulfonyl]carbamoyl}-1-(3,4-methylenedioxyphenyl)methyl)-1-methyl-1H-indole-6-carboxylic acid
• Synonyms: 3-(1-{[(2-methoxy-4-methylphenyl)sulfonyl]carbamoyl}-1-(3,4-methylenedioxyphenyl)methyl)-1-methyl-1H-indole-6-carboxylic acid
• CAS NO: 199589-50-9
• Molecular Weight: 536.562
• Mol File: 199589-50-9.mol
• Article Data: 4

Chemical Properties

• CAS DataBase Reference: 3-(1-{[(2-methoxy-4-methylphenyl)sulfonyl]carbamoyl}-1-(3,4-methylenedioxyphenyl)methyl)-1-methyl-1H-indole-6-carboxylic acid(CAS DataBase Reference)
• NIST Chemistry Reference: 3-(1-{[(2-methoxy-4-methylphenyl)sulfonyl]carbamoyl}-1-(3,4-methylenedioxyphenyl)methyl)-1-methyl-1H-indole-6-carboxylic acid(199589-50-9)
• EPA Substance Registry System: 3-(1-{[(2-methoxy-4-methylphenyl)sulfonyl]carbamoyl}-1-(3,4-methylenedioxyphenyl)methyl)-1-methyl-1H-indole-6-carboxylic acid(199589-50-9)

Safety Data

• Hazardous Substances Data: 199589-50-9(Hazardous Substances Data)

Upstream product

• 216394-11-5 2-methoxy-4-methylbenzenesulfonyl chloride 
• 188670-18-0 2-(1,3-benzodioxol-5-yl)-2-bromoacetic acid 
• 27738-46-1 3,4-(methylenedioxy)mandelic acid 
• 223438-63-9 2-(6-methoxycarbonyl-1-methyl-1H-indol-3-yl)-2-(3,4-methylenedioxyphenyl)acetic acid 
• 125872-95-9 6-bromo-1-methyl-1H-indole 
• 1204-32-6 methyl 1-methylindole-6-carboxylate 
• 52415-29-9 6-bromo-1H-indole 
• 199589-43-0 methyl 3-{1-(1,3-benzodioxol-5-yl)-2-[(2-methoxy-4-methylphenyl)sulfonyl-amino]-2-oxoethyl}-1-methyl-1H-indole-6-carboxylate 

Relevant articles and documents

Generation of gold carbenes in water: Efficient intermolecular trapping of the α-oxo gold carbenoids by indoles and anilines

The efficient intermolecular reaction of gold carbene intermediates, generated via gold-catalyzed alkyne oxidation, with indoles and anilines has been realized in aqueous media. Importantly, it was revealed for the first time that water could dramatically suppress the undesired over-oxidation, providing a general and practical solution to the problem of over-oxidation in gold-catalyzed intermolecular alkyne oxidation with external nucleophiles. This strategy was successfully applied to the formal synthesis of the Pfizer's chiral endothelin antagonist UK-350,926.

The design and synthesis of a novel series of indole derived selective ETA antagonists

Conformational constraint has been used as the key design element in the identification of a series of potent and selective ETA antagonists. The most potent antagonist, 32, (ETA IC50 = 0.55 nM) is 722-fold selective over t